NARS1 and DSCR9

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		NARS1	DSCR9
Description		asparaginyl-tRNA synthetase 1	Down syndrome critical region 9
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cellular_component
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Aminoacyl-tRNA Ligase Activity Asparagine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity	Molecular_function
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Asparaginyl-tRNA Aminoacylation Cell Migration Cerebral Cortex Development	Biological_process
Pathways		Cytosolic tRNA aminoacylation
Drugs		Asparagine
Diseases
GWAS			Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		7 interacting genes: ATXN1 CEBPA DCC DSCR9 HSPB2 LSM1 SUMO2	146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2
Entrez ID		4677	257203
HPRD ID		00154	10925
Ensembl ID		ENSG00000134440	ENSG00000230366
Uniprot IDs		O43776
PDB IDs		4ZYA 5XIX 8H53 8TC7 8TC8 8TC9
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Nuclear Matrix Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 White Fat Cell Proliferation Memory C/EBP Complex Regulation Of Cell Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Somatic Muscle Development POZ Domain Binding Lsm1-7-Pat1 Complex Positive Regulation Of Proteolysis Response To Phenylpropanoid Regulation Of Proteasomal Protein Catabolic Process Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development Positive Regulation Of Protein Catabolic Process Fat Cell Proliferation Poly(G) Binding Regulation Of Cell Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Postsynapse	Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway
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