GNPTAB and STAMBPL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		GNPTAB	STAMBPL1
Description		N-acetylglucosamine-1-phosphate transferase subunits alpha and beta	STAM binding protein like 1
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Endosome Cytosol Membrane
	Molecular Function	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Calcium Ion Binding Protein Binding Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Metal Ion Binding	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding K63-linked Deubiquitinase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Lysosome Organization Protein Secretion Protein Transport N-glycan Processing To Lysosome Secretion Of Lysosomal Enzymes Carbohydrate Phosphorylation Establishment Of Localization In Cell	Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Protein K63-linked Deubiquitination Cellular Response To L-leucine Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways			Metalloprotease DUBs
Drugs
Diseases		Mucolipidosis II and III, including: Mucolipidosis II / I-cell disease; Mucolipidosis III A / Pseudo-Hurler polydystrophy; Mucolipidosis III C
GWAS		Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: AEN APP DISC1 DSCAM DSCR9 FAM90A1 MAPK1 PSMA1 STAMBPL1 ZNF250	38 interacting genes: A2M BIRC5 CALCOCO2 CDC37 CEP72 COPS5 COPS6 DUSP1 ECSIT ENOX2 GCSAML GNPTAB GOLGA2 GOLGA6L9 IKZF3 INCA1 LAX1 LCOR MAGEA6 MAST1 MORN5 PLEKHF2 PNMA1 PSEN1 RAB2A RAB2B REL RNF32 SESN2 SF3B5 SMAD2 SMAD7 TCF4 TRIM27 TRIP13 UBC ZNF835 ZRANB1
Entrez ID		79158	57559
HPRD ID		11350	16486
Ensembl ID		ENSG00000111670	ENSG00000138134
Uniprot IDs		Q3T906	Q96FJ0
PDB IDs		2N6D 7S05 7S06 9BGF 9BGG	2ZNR 2ZNV 7L97
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Monoatomic Cation Homeostasis Trans-synaptic Signaling Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Regulation Of Chemotaxis Cell Body Positive Regulation Of Chemotaxis Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Leukocyte Chemotaxis Neuron Recognition Regulation Of Inflammatory Response Lipoprotein Particle Synaptic Signaling Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Intracellular Monoatomic Ion Homeostasis Microglia Development Glial Cell Development Positive Regulation Of G Protein-coupled Receptor Internalization Synapse Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Axon Extension Positive Regulation Of Axon Extension Positive Regulation Of Axonogenesis Cellular Response To Amino Acid Starvation Cytosine Metabolic Process Interleukin-34-mediated Signaling Pathway Response To Amino Acid Starvation Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone DNA Exonuclease Activity Positive Regulation Of Cellular Component Organization Monoatomic Ion Homeostasis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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