SMPD3

Description		sphingomyelin phosphodiesterase 3
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GO Annotations	Cellular Component	Golgi Cis Cisterna Golgi Membrane Extracellular Region Cytoplasm Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Phosphatidylserine Binding Catalytic Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding Neutral Sphingomyelin Phosphodiesterase Activity Phosphatidic Acid Binding
	Biological Process	Skeletal System Development Ossification Endochondral Ossification Chondrocyte Development Hematopoietic Progenitor Cell Differentiation Regulation Of Leukocyte Migration Chondrocyte Development Involved In Endochondral Bone Morphogenesis Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Signal Transduction Polysaccharide Transport Peptide Hormone Secretion Bone Mineralization Lung Development BMP Signaling Pathway Collagen Metabolic Process Cellular Response To Reactive Oxygen Species Multicellular Organism Growth Positive Regulation Of Mitotic Nuclear Division Platelet-derived Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Smooth Muscle Cell Proliferation Cartilage Development Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Development Respiratory System Development Regulation Of Cartilage Development Cellular Response To Hydrogen Peroxide G1 To G0 Transition Cellular Response To Magnesium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Redox State DNA Biosynthetic Process Extracellular Matrix Assembly Sphingolipid Mediated Signaling Pathway Dentinogenesis Bone Growth Mitotic Nuclear Division Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Peptide Positive Regulation Of Exosomal Secretion
Pathways		TNFR1-mediated ceramide production Glycosphingolipid catabolism
Drugs		Phosphatidyl serine
Diseases
GWAS		Birth weight ( 31043758) Chronic obstructive pulmonary disease in ever smokers ( 33106845) Chronic obstructive pulmonary disease in non-current smokers ( 33106845) Chronic obstructive pulmonary disease x current smoker interaction (2df) ( 33106845) Chronic obstructive pulmonary disease x current smoker interaction (main effect) ( 33106845) Chronic obstructive pulmonary disease x ever smoker interaction (2df) ( 33106845) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340) Hemoglobin levels ( 32327693) Lipoprotein (a) levels ( 33730874) Offspring birth weight ( 31043758) Refractive error ( 32231278)
Novel Interacting Genes		1 novel interacting genes: DSCR9
Interacting Genes		1 interacting genes: DSCR9
Entrez ID		55512
HPRD ID		16154
Ensembl ID		ENSG00000103056
Uniprot IDs		A8K0T6 Q9NY59
PDB IDs		5UVG
Enriched GO Terms of Interacting Partners?		Cellular_component Molecular_function
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