LMO7 and EMD

Number of citations of the paper that reports this interaction (PubMedID 17620012)
114

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		LMO7	EMD
Description		LIM domain 7	emerin
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nuclear Envelope Cytoplasm Mitochondrion Cytosol Focal Adhesion Cell Surface Apical Plasma Membrane	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Spindle Cytosol Microtubule Membrane Spindle Pole Centrosome Nuclear Membrane Cortical Endoplasmic Reticulum TMEM240-body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	Actin Binding Protein Binding Cadherin Binding Beta-tubulin Binding
	Biological Process	Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process	Muscle Contraction Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Nuclear Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation
Pathways		Neddylation Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerization of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases			Emery-Dreifuss muscular dystrophy
GWAS		Age-related hearing impairment ( 34108613) Cutaneous melanoma or hair colour ( 32341527) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29449654 33627673) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Intraocular pressure ( 29617998 29785010 30054594 31959993) Mean corpuscular hemoglobin ( 32888494) Multiple system atrophy (pathologically confirmed) ( 27629089) Obsessive-compulsive disorder ( 30456828) Type 1 diabetes ( 21980299)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		15 interacting genes: ABCA1 ANXA1 CALM1 DAPK3 DSCR9 EMD LRIG3 MDM2 PKM RHOU SRPK2 SUMO2 TBK1 UBAC2 YWHAG	100 interacting genes: ABL1 ABT1 ACTB ACTG2 AEN AKAP8L ANK1 ANKS6 AQP6 AVPI1 BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CCNL2 CD33 CEP70 CERS4 CISD2 CLEC14A COMT COPS6 CPLX4 CREB3 CTNNBIP1 CXorf66 DPPA4 EFHC2 ERMAP FAM209A FATE1 GMCL1 GOLM2 GORAB GPR152 GRAMD2A HSF2BP INCA1 KASH5 KCNJ12 KCNJ18 KCNJ8 KCNN3 KIF9 KIR2DL3 LIME1 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 MEOX1 MEOX2 MMGT1 MRPL45 MTERF4 MTNR1A NCAPH2 NF2 NPDC1 PAK5 PIMREG PSME1 REL RNASEH1 RNF123 SH3GL2 SH3GL3 SLC10A1 SLC35H1 SOWAHB SRC SSMEM1 STX1A SYNE1 TCF23 TMEM174 TMEM200A TMEM201 TMEM52B TMEM80 TMX2 TRAF3IP3 TRIM42 VAV1 WEE2-AS1 YTHDC1 ZFP1 ZFP57 ZFP64 ZNF165 ZNF232 ZNF329 ZNF341 ZNF398 ZNF549 ZNF774
Entrez ID		4008	2010
HPRD ID		05078	02309
Ensembl ID		ENSG00000136153	ENSG00000102119
Uniprot IDs		A0A0A0MTE2 E9PMT2 F8J2B5 F8WD26 Q8WWI1	P50402
PDB IDs		2EAQ	1JEI 2ODC 2ODG 6GHD 6RPR 7NDY
Enriched GO Terms of Interacting Partners?		Vesicle Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Export From Nucleus SUMO Transferase Activity Regulation Of Signal Transduction Protein Metabolic Process Protein Modification Process Cellular Response To Hormone Stimulus Regulation Of Cell Shape Presynaptic Cytosol Regulation Of Intracellular Protein Transport Amyloid Fibril Formation Positive Regulation Of Translation Positive Regulation Of Gene Expression Intracellular Signal Transduction Regulation Of Translation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Signal Transduction Response To Nutrient Levels Sphingolipid Floppase Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Myosin II Filament Organization TMEM240-body Regulation Of Protein Localization Response To Formaldehyde Cellular Response To Vitamin B1 Peptidyl-serine Phosphorylation Positive Regulation Of Translational Initiation Regulation Of Establishment Of Protein Localization Protein Sumoylation Presynapse Spindle Response To Vitamin B3 Regulation Of Multicellular Organismal Process Regulation Of Transport Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Alpha-beta T Cell Differentiation Response To Hormone Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Cycle G1/S Phase Transition Cilium Regulation Of Cell Morphogenesis Regulation Of Cell Cycle Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Post-transcriptional Regulation Of Gene Expression	Protein Binding Inward Rectifier Potassium Channel Activity Fc-gamma Receptor Signaling Pathway
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