CGRRF1 and UBE2U

Data Source:
BioGRID (two hybrid)

		CGRRF1	UBE2U
Description		cell growth regulator with ring finger domain 1	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Intracellular Membrane-bounded Organelle	HULC Complex
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Dental caries ( 23259602) Monobrow thickness ( 26926045) Night sleep phenotypes ( 27126917)	Severe bacterial meningitis ( 31092817)
Interacting Genes		32 interacting genes: AGR3 BET1 CD72 CDIPT CREB3 CYB5B FAM241B FAXDC2 FFAR2 GPR151 GPR152 JAGN1 KLRC1 LAPTM4B LNPEP MARCHF5 MTIF3 PEX10 PGAP2 RHBDD1 SCAMP4 SLC30A3 SLC30A8 SUSD3 TMEM140 TMEM187 TMEM31 TMEM97 TPRG1 UBE2U YIPF6 ZFPL1	68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		10668	148581
HPRD ID		09366	14599
Ensembl ID		ENSG00000100532	ENSG00000177414
Uniprot IDs		Q99675	A0A140VJY9 Q5VVX9
PDB IDs		2EA5	1YRV
Enriched GO Terms of Interacting Partners?
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