UBE2U and RNF181

Data Source:
BioGRID (two hybrid)

		UBE2U	RNF181
Description		ubiquitin conjugating enzyme E2 U	ring finger protein 181
Image			No pdb structure
GO Annotations	Cellular Component	HULC Complex	Cytoplasm
	Molecular Function	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Ubiquitination Protein Autoubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)	Prostate cancer ( 21743467)
Interacting Genes		68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	22 interacting genes: BCL10 BIRC2 BTG1 CARD11 CLK4 MRPS6 NPY5R PEG10 RBCK1 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10
Entrez ID		148581	51255
HPRD ID		14599	14236
Ensembl ID		ENSG00000177414	ENSG00000168894
Uniprot IDs		A0A140VJY9 Q5VVX9	Q9P0P0
PDB IDs		1YRV
Enriched GO Terms of Interacting Partners?
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