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UBE2U and MIB1
Data Source:
BioGRID
(two hybrid)
UBE2U
MIB1
Description
ubiquitin conjugating enzyme E2 U
MIB E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
HULC Complex
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Postsynaptic Density
Cytoplasmic Vesicle
Molecular Function
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Biological Process
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Blood Vessel Development
In Utero Embryonic Development
Somitogenesis
Neural Tube Formation
Heart Looping
Ubiquitin-dependent Protein Catabolic Process
Endocytosis
Notch Signaling Pathway
Protein Ubiquitination
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Endocytosis
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS
Severe bacterial meningitis (
31092817
)
Brain morphology (MOSTest) (
32665545
)
Mean spheric corpuscular volume (
32888494
)
Severe progression in rheumatoid arthritis (
29065906
)
Interacting Genes
68 interacting genes:
ANAPC11
BARD1
BFAR
CADPS2
CBL
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
UBA1
VPS11
VPS41
ZSWIM2
15 interacting genes:
AZI2
BLM
DAB2
DAPK1
EPB41L4A
GABARAP
JAG1
SNX5
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2N
UBE2U
UBE2W
Entrez ID
148581
57534
HPRD ID
14599
06660
Ensembl ID
ENSG00000177414
ENSG00000101752
Uniprot IDs
A0A140VJY9
Q5VVX9
Q86YT6
PDB IDs
1YRV
4TSE
4XI6
4XI7
4XIB
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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