UBE2U and TRIM34

Data Source:
BioGRID (two hybrid)

		UBE2U	TRIM34
Description		ubiquitin conjugating enzyme E2 U	tripartite motif containing 34
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GO Annotations	Cellular Component	HULC Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Molecular_function Zinc Ion Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)	Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	7 interacting genes: BIRC2 MKRN3 MNAT1 TRIM5 UBE2K UBE2U USP2
Entrez ID		148581	53840
HPRD ID		14599	16141
Ensembl ID		ENSG00000177414	ENSG00000258659
Uniprot IDs		A0A140VJY9 Q5VVX9	Q9BYJ4
PDB IDs		1YRV	2EGP
Enriched GO Terms of Interacting Partners?
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