UBE2U and MIB2

Data Source:
BioGRID (two hybrid)

		UBE2U	MIB2
Description		ubiquitin conjugating enzyme E2 U	MIB E3 ubiquitin protein ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	HULC Complex	Ubiquitin Ligase Complex Cytoplasm Early Endosome Cytosol
	Molecular Function	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)	Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)
Interacting Genes		68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	10 interacting genes: ACTA1 ACTC1 BCL10 GRIN2B JAG2 SRPK2 TBK1 UBE2D2 UBE2N UBE2U
Entrez ID		148581	142678
HPRD ID		14599	15905
Ensembl ID		ENSG00000177414	ENSG00000197530
Uniprot IDs		A0A140VJY9 Q5VVX9	Q96AX9
PDB IDs		1YRV
Enriched GO Terms of Interacting Partners?
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