UBE2U and TRIM65

Data Source:
BioGRID (two hybrid)

		UBE2U	TRIM65
Description		ubiquitin conjugating enzyme E2 U	tripartite motif containing 65
Image			No pdb structure
GO Annotations	Cellular Component	HULC Complex	Nucleoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Zinc Ion Binding
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Autophagy
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)	Body mass index ( 29273807) Deep white matter hyperintensities ( 32517579) Psoriasis ( 28537254) Reticulocyte count ( 32888494) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137)
Interacting Genes		68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	12 interacting genes: ANAPC11 IFIH1 MARCHF7 MKRN3 RBCK1 SRPK1 TNRC6A UBE2D2 UBE2U UBE2Z UBE3A VCAM1
Entrez ID		148581	201292
HPRD ID		14599	15569
Ensembl ID		ENSG00000177414	ENSG00000141569
Uniprot IDs		A0A140VJY9 Q5VVX9	Q6PJ69
PDB IDs		1YRV
Enriched GO Terms of Interacting Partners?
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