UBE2U and RNF139

Data Source:
BioGRID (two hybrid)

		UBE2U	RNF139
Description		ubiquitin conjugating enzyme E2 U	ring finger protein 139
Image			No pdb structure
GO Annotations	Cellular Component	HULC Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Integral Component Of Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protease Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-like Protein Transferase Activity Signaling Receptor Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of Translation Protein Phosphopantetheinylation Protein Destabilization ERAD Pathway Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Endoplasmic Reticulum Mannose Trimming Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)
Interacting Genes		68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	6 interacting genes: COPS5 EIF3A UBE2H UBE2U UBE2Z VHL
Entrez ID		148581	11236
HPRD ID		14599	04333
Ensembl ID		ENSG00000177414	ENSG00000170881
Uniprot IDs		A0A140VJY9 Q5VVX9	Q8WU17
PDB IDs		1YRV
Enriched GO Terms of Interacting Partners?
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