UBE2U and PCGF1

Data Source:
BioGRID (two hybrid)

		UBE2U	PCGF1
Description		ubiquitin conjugating enzyme E2 U	polycomb group ring finger 1
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GO Annotations	Cellular Component	HULC Complex	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Protein C-terminus Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Regulation Of Transcription, DNA-templated Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)
Interacting Genes		68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	12 interacting genes: BCOR CALCOCO2 CBX6 CBX7 FCHO1 MUC7 PCGF5 RNF125 RNF2 TRIM55 UBE2D3 UBE2U
Entrez ID		148581	84759
HPRD ID		14599	11404
Ensembl ID		ENSG00000177414	ENSG00000115289
Uniprot IDs		A0A140VJY9 Q5VVX9	Q9BSM1
PDB IDs		1YRV	4HPL 4HPM 5JH5
Enriched GO Terms of Interacting Partners?
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