Wiki-Pi
About
Search
Browse
People
Updates
Search
UBE2U and ANAPC11
Data Source:
BioGRID
(two hybrid)
UBE2U
ANAPC11
Description
ubiquitin conjugating enzyme E2 U
anaphase promoting complex subunit 11
Image
GO Annotations
Cellular Component
HULC Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Nucleolus
Cytosol
Cullin-RING Ubiquitin Ligase Complex
Molecular Function
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Biological Process
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Severe bacterial meningitis (
31092817
)
Interacting Genes
68 interacting genes:
ANAPC11
BARD1
BFAR
CADPS2
CBL
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
UBA1
VPS11
VPS41
ZSWIM2
55 interacting genes:
ANAPC10
ANAPC2
ANAPC4
BANP
BEND2
CAPN11
CCNB1
CDC16
CDC20
CREB5
CRYBA2
CUL5
CYSRT1
DTX2
EFEMP1
EFEMP2
FBXO5
FRS3
FZR1
GPANK1
HSD3B7
IQUB
KRTAP11-1
KRTAP13-2
KRTAP19-2
KRTAP3-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
MAK
MGAT5B
MLKL
NKD2
OXER1
P4HA3
PRKAA2
PRKAB2
PTTG1
RBPMS
RNF111
TCEANC
TEX37
TLE5
TRIM65
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2K
UBE2L1
UBE2S
UBE2U
WWOX
ZAP70
Entrez ID
148581
51529
HPRD ID
14599
12452
Ensembl ID
ENSG00000177414
ENSG00000141552
Uniprot IDs
A0A140VJY9
Q5VVX9
A0A024R8S1
Q9NYG5
PDB IDs
1YRV
2MT5
4R2Y
4UI9
5A31
5G04
5G05
5JG6
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?