NR1I3 and HNF4A

Number of citations of the paper that reports this interaction (PMID 18552123)
11

Data Source:
BioGRID (pull down)

		NR1I3	HNF4A
Gene Name		nuclear receptor subfamily 1, group I, member 3	hepatocyte nuclear factor 4, alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Androgen Receptor Activity Thyroid Hormone Receptor Activity Zinc Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Gene Expression Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Ornithine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Proliferation Response To Glucose Gene Expression Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Glucose Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis SMAD Protein Signal Transduction Regulation Of Growth Hormone Receptor Signaling Pathway Triglyceride Homeostasis Positive Regulation Of Cholesterol Homeostasis
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			C-reactive protein ( 21300955 22939635) Cholesterol, total ( 20686565) HDL cholesterol ( 19060906 20686565) Type 2 diabetes ( 21874001 22158537) Ulcerative colitis ( 19915572 23128233)
Protein-Protein Interactions		18 interactors: CHD9 EIF3I FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC	62 interactors: ANP32B COPS5 CREBBP ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HNF1A MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 SUMO1 SUMO2 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3
Entrez ID		9970	3172
HPRD ID		04858	02612
Ensembl ID		ENSG00000143257	ENSG00000101076
Uniprot IDs		E9PB75 E9PC13 E9PDU3 E9PHC8 F1DAL4 Q14994 Q6GZ76 Q6GZ79 Q6GZ82 Q6GZ89	F1D8S2 F1D8T0 F1D8T1 P41235
PDB IDs		1XV9 1XVP	1PZL 3CBB 3FS1 4B7W 4IQR
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Positive Regulation Of Gene Expression Androgen Receptor Signaling Pathway Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Cellular Biosynthetic Process DNA-templated Transcription, Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Steroid Hormone Gland Development Response To Lipid Response To Organic Cyclic Compound RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Development Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Branching Involved In Thelarche Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Developmental Process Involved In Reproduction Placenta Development Small Molecule Metabolic Process Biosynthetic Process Regulation Of Signaling Regulation Of Gene Expression Mammary Gland Duct Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Lipid Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Reproductive Structure Development Reproductive System Development In Utero Embryonic Development Regulation Of Metabolic Process Cellular Response To Thyroid Hormone Stimulus	Transcription, DNA-templated RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Metabolic Process Response To Hormone Stem Cell Maintenance Cellular Response To Organic Substance
Tagcloud ?		26s activators anchored androstane car carbaldehyde chlorophenyl citco cytosol dichlorobenzyl disrupting disrupts gal1 hcar held hepatocytes homoeostasis imidazo oxime paradoxically phenobarbital proteasomal quiescent repressing sug1 tethering thiazole ubiquitinated xenobiotic	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts
Tagcloud (Difference) ?		26s activators anchored androstane car carbaldehyde chlorophenyl citco cytosol dichlorobenzyl disrupting disrupts gal1 hcar held hepatocytes homoeostasis imidazo oxime paradoxically phenobarbital proteasomal quiescent repressing sug1 tethering thiazole ubiquitinated xenobiotic	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts
Tagcloud (Intersection) ?