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NR1I3 and PSMC4
Number of citations of the paper that reports this interaction (PubMedID
8603043
)
0
Data Source:
BioGRID
(two hybrid)
NR1I3
PSMC4
Description
nuclear receptor subfamily 1 group I member 3
proteasome 26S subunit, ATPase 4
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Ciliary Basal Body
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Sequence-specific DNA Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Nucleotide Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Proteasome-activating Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Regulation Of DNA-templated Transcription
Signal Transduction
Cell Differentiation
Intracellular Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Blastocyst Development
Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Doxylamine
Meclizine
Ketoconazole
Atorvastatin
Pheniramine
Prasterone
16,17-Androstene-3-Ol
Resveratrol
Cholesterol
Phenolphthalein
3,20-Pregnanedione
Hexestrol
Triclosan
Diseases
GWAS
Interacting Genes
18 interacting genes:
CHD9
DNMT3L
FTH1
HNF4A
IGH
MAP4
MED1
NCOA1
NCOA3
NR0B2
POU1F1
PPARGC1A
PSMC4
PSMC5
RXRA
SNRPD3
SNX13
SRC
17 interacting genes:
CEBPA
FILNC1
NPM1
NR1I3
OGT
PAAF1
PSMC2
PSMC3
PSMC5
PSMD10
RNF2
RORB
SUMO2
TRAP1
UBASH3A
UBLCP1
ZFAND1
Entrez ID
9970
5704
HPRD ID
04858
04085
Ensembl ID
ENSG00000143257
ENSG00000013275
Uniprot IDs
F1DAL4
Q14994
A8K2M0
P43686
PDB IDs
1XV9
1XVP
2DVW
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
Enriched GO Terms of Interacting Partners
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Nuclear Receptor Binding
Nuclear Receptor-mediated Signaling Pathway
Intracellular Receptor Signaling Pathway
Peroxisome Proliferator Activated Receptor Signaling Pathway
Hormone-mediated Signaling Pathway
Nuclear Retinoic Acid Receptor Binding
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Steroid Hormone Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nuclear Thyroid Hormone Receptor Binding
Negative Regulation Of RNA Metabolic Process
Chromatin
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
MRNA Transcription By RNA Polymerase II
Proteasome-activating Activity
Regulation Of Thyroid Hormone Receptor Signaling Pathway
LBD Domain Binding
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Nucleus
MRNA Transcription
Positive Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Peroxisome Proliferator Activated Receptor Binding
Regulation Of Vitamin D Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of RNA Metabolic Process
General Transcription Initiation Factor Binding
Proteasome Regulatory Particle, Base Subcomplex
Progesterone Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Nuclear Vitamin D Receptor Binding
Proteasomal Protein Catabolic Process
Rhythmic Process
Proteasome Accessory Complex
Nuclear Retinoid X Receptor Binding
Positive Regulation Of Keratinocyte Differentiation
Branching Involved In Mammary Gland Duct Morphogenesis
Monocyte Differentiation
Nucleoplasm
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Proteasome Regulatory Particle, Base Subcomplex
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Proteasome Complex
Proteasome-activating Activity
Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Protein Metabolic Process
Proteasome Accessory Complex
Regulation Of Protein Metabolic Process
Nucleoplasm
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
ATP Hydrolysis Activity
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
DNA-binding Transcription Factor Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Macrophage Differentiation
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Regulation Of MRNA Stability Involved In Cellular Response To UV
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
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