NR1I3 and SNX13

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NR1I3	SNX13
Description		nuclear receptor subfamily 1 group I member 3	sorting nexin 13
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton	Endosome Early Endosome Membrane Early Endosome Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of DNA-templated Transcription Signal Transduction Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Intracellular Protein Transport Negative Regulation Of Signal Transduction Protein Transport Positive Regulation Of GTPase Activity
Pathways
Drugs		Doxylamine Meclizine Ketoconazole Atorvastatin Pheniramine Prasterone 16,17-Androstene-3-Ol Resveratrol Cholesterol Phenolphthalein 3,20-Pregnanedione Hexestrol Triclosan
Diseases
GWAS			Adiponectin levels ( 31178129) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Chronic widespread musculoskeletal pain ( 33331911) Creatine kinase levels ( 29403010) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 30275531 24097068) HDL cholesterol levels ( 30698716 28334899 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Lactate dehydrogenase levels ( 29403010) LDL cholesterol levels x long total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Metabolic syndrome ( 31589552) Neutrophil count ( 32888494) Parkinson's disease progression (composite) ( 33111402) Severe influenza A (H1N1) infection ( 26379185) Tea consumption ( 31046077) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		18 interacting genes: CHD9 DNMT3L FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC	5 interacting genes: G6PC1 GNAS KLF15 NR1I3 TDP2
Entrez ID		9970	23161
HPRD ID		04858	09418
Ensembl ID		ENSG00000143257	ENSG00000071189
Uniprot IDs		F1DAL4 Q14994	B3KN60 Q86XC4 Q9NSH0 Q9Y5W8
PDB IDs		1XV9 1XVP	7WF6
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Retinoic Acid Receptor Binding Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II Proteasome-activating Activity Regulation Of Thyroid Hormone Receptor Signaling Pathway LBD Domain Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus MRNA Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding Regulation Of Vitamin D Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process General Transcription Initiation Factor Binding Proteasome Regulatory Particle, Base Subcomplex Progesterone Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Vitamin D Receptor Binding Proteasomal Protein Catabolic Process Rhythmic Process Proteasome Accessory Complex Nuclear Retinoid X Receptor Binding Positive Regulation Of Keratinocyte Differentiation Branching Involved In Mammary Gland Duct Morphogenesis Monocyte Differentiation Nucleoplasm	Cellular Response To Peptide Hormone Stimulus Response To Peptide Hormone Cellular Response To Hormone Stimulus 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Response To Hormone Carbohydrate Homeostasis Glucose Homeostasis Response To Resveratrol Glucose-6-phosphatase Activity Cellular Response To Oxygen-containing Compound Response To Insulin Chemical Homeostasis Glucose-6-phosphate Transport Hair Follicle Placode Formation Mu-type Opioid Receptor Binding Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase Regulator Activity Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Developmental Growth Glycogen Catabolic Process Urate Metabolic Process Response To Stilbenoid Phosphotransferase Activity, Alcohol Group As Acceptor Phosphate Ion Binding Response To Stress Glucose 6-phosphate Metabolic Process Homeostatic Process Regulation Of Metabolic Process Response To Caloric Restriction Cellular Response To Acidic PH Guanyl Nucleotide Binding Vascular Endothelial Cell Response To Fluid Shear Stress Response To Catecholamine Renal Water Homeostasis G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Lyase Activity Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Skeletal Muscle Contraction Positive Regulation Of Adenylate Cyclase Activity
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