NR1I3 and PPARGC1A

Number of citations of the paper that reports this interaction (PMID 15572376)
7

Data Source:
HPRD (two hybrid)

		NR1I3	PPARGC1A
Gene Name		nuclear receptor subfamily 1, group I, member 3	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Cytosol PML Body
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Androgen Receptor Activity Thyroid Hormone Receptor Activity Zinc Ion Binding	Nucleotide Binding RNA Polymerase II Transcription Cofactor Activity DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Androgen Receptor Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Gene Expression Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Temperature Homeostasis Cellular Glucose Homeostasis Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Protein Complex Assembly Organelle Organization Mitochondrion Organization Digestion Circadian Rhythm Androgen Metabolic Process RNA Splicing Response To Cold Positive Regulation Of Mitochondrion Organization Response To Muscle Activity Fatty Acid Oxidation Respiratory Electron Transport Chain Androgen Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Response To Statin Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Flavone Metabolic Process Cellular Response To Nitrite Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Epinephrine Response To Norepinephrine Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Negative Regulation Of Receptor Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Energy Homeostasis Positive Regulation Of ATP Biosynthetic Process
Pathways			PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		18 interactors: CHD9 EIF3I FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC	40 interactors: CAPNS1 CDK6 CREBBP CREBZF ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RXRA SIRT1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF2
Entrez ID		9970	10891
HPRD ID		04858	05155
Ensembl ID		ENSG00000143257	ENSG00000109819
Uniprot IDs		E9PB75 E9PC13 E9PDU3 E9PHC8 F1DAL4 Q14994 Q6GZ76 Q6GZ79 Q6GZ82 Q6GZ89	I3RTT5 I3RTT6 Q9UBK2
PDB IDs		1XV9 1XVP	1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Positive Regulation Of Gene Expression Androgen Receptor Signaling Pathway Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Cellular Biosynthetic Process DNA-templated Transcription, Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Steroid Hormone Gland Development Response To Lipid Response To Organic Cyclic Compound RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Development Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Branching Involved In Thelarche Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Developmental Process Involved In Reproduction Placenta Development Small Molecule Metabolic Process Biosynthetic Process Regulation Of Signaling Regulation Of Gene Expression Mammary Gland Duct Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Lipid Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Reproductive Structure Development Reproductive System Development In Utero Embryonic Development Regulation Of Metabolic Process Cellular Response To Thyroid Hormone Stimulus	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Steroid Hormone Mediated Signaling Pathway RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Cellular Response To Steroid Hormone Stimulus Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Steroid Hormone Cellular Nitrogen Compound Metabolic Process Cellular Response To Lipid Biosynthetic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Regulation Of Metabolic Process Response To Hormone Negative Regulation Of Biosynthetic Process Response To Lipid Cellular Response To Hormone Stimulus Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Cellular Response To Organic Substance Response To Organic Substance
Tagcloud ?		26s activators anchored androstane car carbaldehyde chlorophenyl citco cytosol dichlorobenzyl disrupting disrupts gal1 hcar held hepatocytes homoeostasis imidazo oxime paradoxically phenobarbital proteasomal quiescent repressing sug1 tethering thiazole ubiquitinated xenobiotic	ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam
Tagcloud (Difference) ?		26s activators anchored androstane car carbaldehyde chlorophenyl citco cytosol dichlorobenzyl disrupting disrupts gal1 hcar held hepatocytes homoeostasis imidazo oxime paradoxically phenobarbital proteasomal quiescent repressing sug1 tethering thiazole ubiquitinated xenobiotic	ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam
Tagcloud (Intersection) ?