NR1I3 and SNRPD3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NR1I3	SNRPD3
Description		nuclear receptor subfamily 1 group I member 3	small nuclear ribonucleoprotein D3 polypeptide
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton	Commitment Complex Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Telomerase Holoenzyme Complex Cytoplasm Cytosol Nuclear Body Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Protein Binding Enzyme Binding Telomerase RNA Binding Histone Pre-mRNA DCP Binding U7 SnRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of DNA-templated Transcription Signal Transduction Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing Protein Methylation RNA Splicing 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly
Pathways			SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery
Drugs		Doxylamine Meclizine Ketoconazole Atorvastatin Pheniramine Prasterone 16,17-Androstene-3-Ol Resveratrol Cholesterol Phenolphthalein 3,20-Pregnanedione Hexestrol Triclosan
Diseases
GWAS			Acne (severe) ( 24927181) Gamma glutamyl transferase levels ( 32084209)
Interacting Genes		18 interacting genes: CHD9 DNMT3L FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC	28 interacting genes: CASP8 CEBPA CRY1 DDX20 FNDC3B GEMIN2 GEMIN5 GEMIN6 GEMIN7 IL12RB1 IL7R LSM3 LSM7 NR1I3 NTAQ1 PRMT5 RBL1 SMN1 SMN2 SNRPB SNRPE SNRPG SREK1 STRAP STXBP2 STXBP3 TRDMT1 WDR77
Entrez ID		9970	6634
HPRD ID		04858	03039
Ensembl ID		ENSG00000143257	ENSG00000100028
Uniprot IDs		F1DAL4 Q14994	P62318
PDB IDs		1XV9 1XVP	1D3B 3CW1 3JCR 3PGW 3VRI 4PJO 4WZJ 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6V4X 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y 7DVQ 7EVO 7QTT 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8R7N 8RC0 8RM5 8RO2 8Y6O 8Y7E 9FMD 9GBW 9GC0 9GCL
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Retinoic Acid Receptor Binding Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II Proteasome-activating Activity Regulation Of Thyroid Hormone Receptor Signaling Pathway LBD Domain Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus MRNA Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding Regulation Of Vitamin D Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process General Transcription Initiation Factor Binding Proteasome Regulatory Particle, Base Subcomplex Progesterone Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Vitamin D Receptor Binding Proteasomal Protein Catabolic Process Rhythmic Process Proteasome Accessory Complex Nuclear Retinoid X Receptor Binding Positive Regulation Of Keratinocyte Differentiation Branching Involved In Mammary Gland Duct Morphogenesis Monocyte Differentiation Nucleoplasm	SMN-Sm Protein Complex Spliceosomal SnRNP Assembly SMN Complex Protein-RNA Complex Assembly Gemini Of Cajal Bodies RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing MRNA Metabolic Process RNA Processing Spliceosomal Complex Assembly RNA Metabolic Process Methylosome MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex U2-type Precatalytic Spliceosome RNA Binding Protein-containing Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleoplasm U12-type Spliceosomal Complex Protein-containing Complex Organization U7 SnRNP 7-methylguanosine Cap Hypermethylation Catalytic Step 2 Spliceosome Macromolecule Metabolic Process U4 SnRNP Cellular Component Assembly Macromolecule Methylation Nucleus Nuclear Body Small Nuclear Ribonucleoprotein Complex Cytosol U2 SnRNP Binding U2-type Prespliceosome DNA-templated Transcription Termination U1 SnRNP Precatalytic Spliceosome U5 SnRNP RNA Methylation Tertiary Granule U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Presynaptic Dense Core Vesicle Exocytosis U2-type Catalytic Step 2 Spliceosome Methylation Lsm1-7-Pat1 Complex
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