SLC23A1 and KRT31

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SLC23A1	KRT31
Gene Name		solute carrier family 23 (ascorbic acid transporter), member 1	keratin 31, type I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Membrane Apical Plasma Membrane Intracellular Organelle Extracellular Vesicular Exosome	Extracellular Space Intermediate Filament Extracellular Vesicular Exosome
	Molecular Function	Protein Binding L-ascorbate:sodium Symporter Activity Sodium Ion Transmembrane Transporter Activity Nucleobase Transmembrane Transporter Activity L-ascorbic Acid Transporter Activity Dehydroascorbic Acid Transporter Activity Sodium-dependent L-ascorbate Transmembrane Transporter Activity	Structural Constituent Of Cytoskeleton
	Biological Process	Nucleobase-containing Compound Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Sodium Ion Transport Brain Development Response To Toxic Substance Nucleobase Transport L-ascorbic Acid Transport L-ascorbic Acid Metabolic Process Lung Development Vitamin Transmembrane Transport Sodium Ion Transmembrane Transport Small Molecule Metabolic Process Dehydroascorbic Acid Transport Transepithelial L-ascorbic Acid Transport	Epidermis Development
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Vitamin C
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ADAMTSL4 AHCYL1 KRT31 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 MTUS2 NOTCH2NL	181 interactors: ABI2 AES AGR2 ALDH3B1 ALS2CR11 AMOT AMOTL2 ANKRD36BP1 AQP1 AQP5 ARHGAP35 ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 BEX2 BTC BYSL C12orf49 C19orf73 C1orf109 C1orf216 C5orf60 C6orf165 CA6 CARD9 CARKD CATIP CCDC112 CCDC120 CCDC17 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK18 CDKN1A CEP57 CEP57L1 CEP70 CHCHD2 CHRNG CLDN2 COA5 COMT COX5A COX5B CRH CTSG DGCR6L DHX37 DMRT3 DTNB EIF4E2 EXOC8 FAM103A1 FAM110A FAM124B FAM71C FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FKBP1B FOXB1 GEM GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GPS2 GSTP1 HAUS1 HDAC4 HGS HOXA1 HSPA12B HSPD1 ICAM4 INPP5D INPP5K INSR JOSD1 KIFC3 KLC1 KLC4 KLHL38 KRT2 KRT5 KRT6A KRT6B KRT6C KRT71 KRT77 KRT79 KRT8 KRT81 KRT83 LATS1 LCE4A LENG1 LIN37 LINC00238 LINC00526 LMF2 LMO4 LONRF1 MAP3K7CL MAPKBP1 MARK4 MRPL40 NAV1 NEK6 NPBWR2 OTUB2 P2RX7 PDE4DIP PGLS PIN1 PKN1 PPP1R18 PRF1 PRKAA2 PRR19 PSMA1 PSMG2 PSPC1 PTGER3 PTPMT1 RADIL RCOR3 RIBC1 RPUSD3 RSPH14 SCNM1 SEMA4C SHC3 SIRPA SLC15A3 SLC23A1 SLC25A6 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SPATA24 SPON2 SRSF2 SSX2IP TAPBPL THAP7 TMEM106C TMEM231 TMSB4X TRAF4 TROAP TSG101 TTC23 TXLNA USHBP1 UTP23 UXT WDR25 WDYHV1 ZFYVE21 ZNF124 ZNF148 ZNF20 ZNF569 ZNF572 ZNF69 ZNRF2P1
Entrez ID		9963	3881
HPRD ID		04810	03047
Ensembl ID		ENSG00000170482	ENSG00000094796
Uniprot IDs		Q9UHI7	Q15323
PDB IDs
Enriched GO Terms of Interacting Partners?			Cellular Process Organelle Organization Epidermis Development Anatomical Structure Development Developmental Process Negative Regulation Of Cellular Metabolic Process Cytoskeleton Organization Positive Regulation Of Urine Volume G2/M Transition Of Mitotic Cell Cycle Gene Expression Regulation Of Body Fluid Levels Epithelium Development RNA Metabolic Process Regulation Of Interleukin-6 Production Carbon Dioxide Transport Response To Organic Substance Regulation Of Glycolytic Process Mitotic Cell Cycle Process Hippo Signaling Negative Regulation Of Biosynthetic Process Positive Regulation Of Interleukin-6 Production Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Pancreatic Juice Secretion Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Regulation Of MAPK Cascade Regulation Of Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Cell Cycle Phase Transition Multicellular Organismal Development Bicarbonate Transport Cell Volume Homeostasis Cell Death Death Interaction With Symbiont Negative Regulation Of Signaling Transcription, DNA-templated Mitotic Cell Cycle Regulation Of Protein Metabolic Process Apoptotic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Fungus Cellular Response To Extracellular Stimulus Cellular Metabolic Process Programmed Cell Death RNA Biosynthetic Process
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