SLC23A1 and KRTAP10-5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SLC23A1	KRTAP10-5
Gene Name		solute carrier family 23 (ascorbic acid transporter), member 1	keratin associated protein 10-5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Membrane Apical Plasma Membrane Intracellular Organelle Extracellular Vesicular Exosome	Keratin Filament
	Molecular Function	Protein Binding L-ascorbate:sodium Symporter Activity Sodium Ion Transmembrane Transporter Activity Nucleobase Transmembrane Transporter Activity L-ascorbic Acid Transporter Activity Dehydroascorbic Acid Transporter Activity Sodium-dependent L-ascorbate Transmembrane Transporter Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Sodium Ion Transport Brain Development Response To Toxic Substance Nucleobase Transport L-ascorbic Acid Transport L-ascorbic Acid Metabolic Process Lung Development Vitamin Transmembrane Transport Sodium Ion Transmembrane Transport Small Molecule Metabolic Process Dehydroascorbic Acid Transport Transepithelial L-ascorbic Acid Transport
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Vitamin C
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ADAMTSL4 AHCYL1 KRT31 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 MTUS2 NOTCH2NL	108 interactors: ADAMTSL4 AEN ALDH3B1 AMOTL2 BCL6B BMP7 BYSL C11orf87 C19orf66 C9orf9 CARD9 CHRD CNNM3 CREB5 DHX57 ECE1 EIF4E2 ENKD1 FAM74A4 FAM76B FARS2 GATA1 GLIDR GLRX3 GNE GOLGA8EP HHEX HOXA1 HPCAL1 KRTAP10-3 KRTAP10-7 KRTAP12-1 KRTAP12-2 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE3C LCE3E LCE4A LIMS2 LUZP4 MEOX2 MOBP MT1DP MXI1 NAA10 NOTCH2NL NPDC1 NR4A1 NUFIP2 OTX1 POM121L8P PRKAB2 PRR13 PVRL2 SCNM1 SLC23A1 SLC6A20 SMCP SPATA3 SPRY1 SPRY2 STK16 TBC1D16 THAP10 TNP2 TNS2 TRPV6 TULP3 TXNDC5 TYMSOS UTP23 WDYHV1 WT1-AS ZBTB24 ZBTB48 ZFYVE21 ZNF20 ZNF264 ZNF273 ZNF286A ZNF32 ZNF320 ZNF329 ZNF34 ZNF417 ZNF433 ZNF439 ZNF559 ZNF572 ZNF587 ZNF670 ZNF679 ZNF697 ZNF707 ZNF785 ZNF792 ZSCAN21 ZSCAN26
Entrez ID		9963	386680
HPRD ID		04810	11191
Ensembl ID		ENSG00000170482
Uniprot IDs		Q9UHI7	P60370
PDB IDs
Enriched GO Terms of Interacting Partners?			Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Biosynthetic Process Keratinization Regulation Of Nitrogen Compound Metabolic Process Keratinocyte Differentiation Regulation Of Metabolic Process Epidermal Cell Differentiation Epithelium Development Epidermis Development Cellular Process Cellular Metabolic Process Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Skin Development Tissue Development Regulation Of Cellular Process Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Organ Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryonic Neurocranium Morphogenesis Penetration Of Zona Pellucida Embryo Development Epithelial Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Bud Elongation Involved In Lung Branching Pattern Specification Process Embryonic Organ Development Negative Regulation Of Protein Serine/threonine Kinase Activity Embryonic Morphogenesis Lung Morphogenesis Anterior/posterior Pattern Specification Respiratory Tube Development Negative Regulation Of Ras GTPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter
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