CDC27 and HSF2

Number of citations of the paper that reports this interaction (PubMedID 20937767)
105

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CDC27	HSF2
Description		cell division cycle 27	heat shock transcription factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Neuron Projection Development Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Regulation Of DNA-templated Transcription Spermatogenesis Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Diffusing capacity of carbon monoxide ( 30694715) Hip circumference adjusted for BMI ( 34021172)	Atrial fibrillation ( 30061737 29892015 28416822) Disease progression in age-related macular degeneration ( 29346644) Lymphocyte count ( 32888494 27863252) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Pulse pressure ( 27841878 30224653) Red blood cell count ( 32888494) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Word reading ( 30741946)
Interacting Genes		30 interacting genes: ADNP ANAPC1 ANAPC10 ANAPC2 ANAPC7 BUB1B CASP3 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FZR1 GKN1 HOXC10 HSF2 MAD2L1 PABPC4 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBC UBE2S	20 interacting genes: CDC20 CDC27 CEP76 CUL3 DERA HSF1 HSF2BP HSPA4 MECOM MTUS2 NCAPG NUP62 PCGF2 PICK1 PPP2R1A SUMO2 SUMO3 TPM3 TRIM54 UBE2I
Entrez ID		996	3298
HPRD ID		00304	00779
Ensembl ID		ENSG00000004897	ENSG00000025156
Uniprot IDs		B4DL80 G5EA36 P30260	Q03933 Q9BS48
PDB IDs		3T1N 4RG6 4RG7 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9FGQ 9GAW	5D8K 5D8L 5HDK 7DCI 7DCU
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Mitotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Regulation Of Chromosome Segregation Regulation Of Nuclear Division Modification-dependent Protein Catabolic Process Nucleoplasm Regulation Of Chromosome Organization Protein Catabolic Process Proteasomal Protein Catabolic Process Metaphase/anaphase Transition Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Binding Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Chromosome Separation Ubiquitin Ligase Activator Activity Protein Ubiquitination Post-translational Protein Modification Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification By Small Protein Conjugation Mitotic Checkpoint Complex Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification Process Catabolic Process Protein K48-linked Ubiquitination Proteolysis Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Cytosol Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Chromosome Separation Cell Cycle Phase Transition	Cytoskeleton Regulation Of Cell Cycle Female Meiotic Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Organelle Organization Cytoplasm Centrosome Positive Regulation Of Chromosome Separation PML Body Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Nuclear Division Spindle Pole Positive Regulation Of Cell Cycle Protein Sumoylation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Separation Meiotic Nuclear Division Protein Modification By Small Protein Conjugation Cell Division Protein Tag Activity Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization SUMO Transferase Activity Regulation Of Sister Chromatid Segregation RNA Polymerase II Transcription Initiation Surveillance Post-translational Protein Modification Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Mitotic Nuclear Division Regulation Of Centriole Replication Nucleoplasm Ubiquitin-like Protein Ligase Binding Cytosol Positive Regulation Of Mitotic Cell Cycle Presynaptic Cytosol Postsynaptic Cytosol Mitotic Spindle Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Nuclear RNA Surveillance Cell Cycle Phase Transition Chromosome, Centromeric Region Kinetochore Chromosome RNA Surveillance
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