CDC27 and PTTG1

Number of citations of the paper that reports this interaction (PMID 16921029)
58

Data Source:
BioGRID (pull down, enzymatic study)

		CDC27	PTTG1
Gene Name		cell division cycle 27	pituitary tumor-transforming 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Spindle Microtubule	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase Binding	Sequence-specific DNA Binding Transcription Factor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding
	Biological Process	Mitotic Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination	Mitotic Cell Cycle DNA Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Chromosome Segregation Mitotic Nuclear Division Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Division
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins
Drugs
Diseases
GWAS			Insulin-related traits ( 22791750) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		30 interactors: ADNP ANAPC10 ANAPC2 ANAPC7 BUB1B CASP3 CCNA2 CCNB1 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FBXO5 FZR1 GKN1 HOXC10 HSF2 MAD2L1 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBE2S	15 interactors: ANAPC11 AURKA CAMK2A CDC20 CDC27 CDK1 CUL1 DNAJA1 FZR1 PPP2R5A PTTG1IP RPS10 TP53 UBE4A XRCC6
Entrez ID		996	9232
HPRD ID		00304	04998
Ensembl ID		ENSG00000004897	ENSG00000164611
Uniprot IDs		B4DL80 G5EA36 P30260	O95997 Q6IAL9
PDB IDs		3T1N
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Ligase Activity Mitotic Nuclear Division Cell Cycle Process Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Cell Cycle Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Cycle Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Mitotic Spindle Checkpoint Negative Regulation Of Protein Catabolic Process	Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Mitotic Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Cycle Process Cell Cycle Checkpoint Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Catabolic Process Regulation Of Cell Cycle Process Protein K11-linked Ubiquitination Regulation Of Cell Division
Tagcloud ?		aiming applying backgroundosteosarcoma chromotripsis cnvs conclusionsthe confirmative ei24 exome germline homodimer igf1 igf2 indels markwe metastasizing methodsfor muc4 mucin os qualify rearrangements resultsin seq snvs softwares somatic tumorous urgent	coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley
Tagcloud (Difference) ?		aiming applying backgroundosteosarcoma chromotripsis cnvs conclusionsthe confirmative ei24 exome germline homodimer igf1 igf2 indels markwe metastasizing methodsfor muc4 mucin os qualify rearrangements resultsin seq snvs softwares somatic tumorous urgent	coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley
Tagcloud (Intersection) ?