CDC27 and PTTG1

Number of citations of the paper that reports this interaction (PubMedID 35440621)
87

Data Source:
BioGRID (pull down)

		CDC27	PTTG1
Description		cell division cycle 27	PTTG1 regulator of sister chromatid separation, securin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding Molecular Function Activator Activity
	Biological Process	Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Neuron Projection Development Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	DNA Repair DNA Damage Response Chromosome Segregation Spermatogenesis Homologous Chromosome Segregation Chromosome Organization Cell Division
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids
Drugs
Diseases
GWAS		Body mass index ( 26426971) Diffusing capacity of carbon monoxide ( 30694715) Hip circumference adjusted for BMI ( 34021172)	Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 19838195 21408207 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		30 interacting genes: ADNP ANAPC1 ANAPC10 ANAPC2 ANAPC7 BUB1B CASP3 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FZR1 GKN1 HOXC10 HSF2 MAD2L1 PABPC4 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBC UBE2S	29 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC4 AURKA CAMK2A CDC20 CDC27 CDC34 CDH1 CDK1 CFTR CRK CUL1 DNAJA1 FZR1 KEAP1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2N UBE4A UBR5 XRCC6 ZFAND5
Entrez ID		996	9232
HPRD ID		00304	04998
Ensembl ID		ENSG00000004897	ENSG00000164611
Uniprot IDs		B4DL80 G5EA36 P30260	O95997 Q6IAL9
PDB IDs		3T1N 4RG6 4RG7 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9FGQ 9GAW	7NJ0 7NJ1
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Mitotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Regulation Of Chromosome Segregation Regulation Of Nuclear Division Modification-dependent Protein Catabolic Process Nucleoplasm Regulation Of Chromosome Organization Protein Catabolic Process Proteasomal Protein Catabolic Process Metaphase/anaphase Transition Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Binding Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Chromosome Separation Ubiquitin Ligase Activator Activity Protein Ubiquitination Post-translational Protein Modification Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification By Small Protein Conjugation Mitotic Checkpoint Complex Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification Process Catabolic Process Protein K48-linked Ubiquitination Proteolysis Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Cytosol Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Chromosome Separation Cell Cycle Phase Transition	Proteasomal Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Anaphase-promoting Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Protein Ubiquitination Protein Branched Polyubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Meiotic Cell Cycle Macromolecule Catabolic Process Regulation Of Chromosome Segregation Proteolysis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Regulation Of Cell Cycle Process Catabolic Process Cell Division Cytosol Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Protein Metabolic Process Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Response To Oxidative Stress Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Protein-containing Complex Ubiquitin-protein Transferase Activator Activity Regulation Of Cell Cycle Phase Transition Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Cullin-RING Ubiquitin Ligase Complex
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