CDC27 and HOXC10

Number of citations of the paper that reports this interaction (PubMedID 12853486)
57

Data Source:
HPRD (in vitro, in vivo)

		CDC27	HOXC10
Description		cell division cycle 27	homeobox C10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Protein Binding Protein Phosphatase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Neuron Projection Development Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Spinal Cord Motor Neuron Cell Fate Specification Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Neuromuscular Process Negative Regulation Of Cold-induced Thermogenesis
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Diffusing capacity of carbon monoxide ( 30694715) Hip circumference adjusted for BMI ( 34021172)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		30 interacting genes: ADNP ANAPC1 ANAPC10 ANAPC2 ANAPC7 BUB1B CASP3 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FZR1 GKN1 HOXC10 HSF2 MAD2L1 PABPC4 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBC UBE2S	5 interacting genes: CDC27 EGFR NUP205 USP21 YWHAG
Entrez ID		996	3226
HPRD ID		00304	05710
Ensembl ID		ENSG00000004897	ENSG00000180818
Uniprot IDs		B4DL80 G5EA36 P30260	Q53XI4 Q9NYD6
PDB IDs		3T1N 4RG6 4RG7 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9FGQ 9GAW
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Mitotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Regulation Of Chromosome Segregation Regulation Of Nuclear Division Modification-dependent Protein Catabolic Process Nucleoplasm Regulation Of Chromosome Organization Protein Catabolic Process Proteasomal Protein Catabolic Process Metaphase/anaphase Transition Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Binding Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Chromosome Separation Ubiquitin Ligase Activator Activity Protein Ubiquitination Post-translational Protein Modification Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification By Small Protein Conjugation Mitotic Checkpoint Complex Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification Process Catabolic Process Protein K48-linked Ubiquitination Proteolysis Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Cytosol Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Chromosome Separation Cell Cycle Phase Transition
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