CDC27 and CDC26

Number of citations of the paper that reports this interaction (PubMedID 10922056)
42

Data Source:
HPRD (in vivo)

		CDC27	CDC26
Description		cell division cycle 27	cell division cycle 26
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Binding Protein Phosphatase Binding	Protein Binding
	Biological Process	Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Neuron Projection Development Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Diffusing capacity of carbon monoxide ( 30694715) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		30 interacting genes: ADNP ANAPC1 ANAPC10 ANAPC2 ANAPC7 BUB1B CASP3 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FZR1 GKN1 HOXC10 HSF2 MAD2L1 PABPC4 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBC UBE2S	3 interacting genes: ANAPC2 CDC27 LATS1
Entrez ID		996	246184
HPRD ID		00304	13012
Ensembl ID		ENSG00000004897	ENSG00000176386
Uniprot IDs		B4DL80 G5EA36 P30260	Q8NHZ8
PDB IDs		3T1N 4RG6 4RG7 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9FGQ 9GAW	3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Mitotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Regulation Of Chromosome Segregation Regulation Of Nuclear Division Modification-dependent Protein Catabolic Process Nucleoplasm Regulation Of Chromosome Organization Protein Catabolic Process Proteasomal Protein Catabolic Process Metaphase/anaphase Transition Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Binding Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Chromosome Separation Ubiquitin Ligase Activator Activity Protein Ubiquitination Post-translational Protein Modification Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification By Small Protein Conjugation Mitotic Checkpoint Complex Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification Process Catabolic Process Protein K48-linked Ubiquitination Proteolysis Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Cytosol Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Chromosome Separation Cell Cycle Phase Transition	Metaphase/anaphase Transition Of Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Branched Polyubiquitination Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Protein K11-linked Ubiquitination Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Reproductive Process Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Cell Cycle Spindle Regulation Of Chromosome Organization Protein Complex Involved In Cell Adhesion Regulation Of Organelle Organization Negative Regulation Of Regulatory T Cell Differentiation Protein Polyubiquitination Regulation Of Synapse Organization Positive Regulation Of Synapse Maturation Regulation Of Developmental Growth Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Plasticity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Cullin-RING Ubiquitin Ligase Complex Regulation Of Postsynaptic Density Assembly Negative Regulation Of B Cell Proliferation Proteasomal Protein Catabolic Process Mammary Gland Epithelial Cell Differentiation Regulation Of Postsynaptic Specialization Assembly Positive Regulation Of Hippo Signaling Regulation Of Excitatory Synapse Assembly Regulation Of Mitotic Cell Cycle NLRP3 Inflammasome Complex Assembly Clathrin-coated Endocytic Vesicle Positive Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Programmed Cell Death Hippo Signaling Regulation Of Synapse Maturation Protein Catabolic Process Protein Ubiquitination
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