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CDC27 and GKN1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
CDC27
GKN1
Description
cell division cycle 27
gastrokine 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Centrosome
Spindle
Cytosol
Cytoskeleton
Mitotic Spindle
Extracellular Region
Extracellular Space
Cytoplasm
Golgi Apparatus
Endomembrane System
Secretory Granule
Molecular Function
Protein Binding
Protein Phosphatase Binding
Protein Binding
Growth Factor Activity
Biological Process
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Neuron Projection Development
Cell Division
Regulation Of Meiotic Cell Cycle
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein Branched Polyubiquitination
Signal Transduction
Digestion
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Division
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Diffusing capacity of carbon monoxide (
30694715
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
30 interacting genes:
ADNP
ANAPC1
ANAPC10
ANAPC2
ANAPC7
BUB1B
CASP3
CDC16
CDC20
CDC26
CKS1B
COMT
CTNNB1
DCPS
FZR1
GKN1
HOXC10
HSF2
MAD2L1
PABPC4
PIN1
PPP5C
PTEN
PTTG1
RB1
SKIL
SMAD2
SMAD3
UBC
UBE2S
12 interacting genes:
AQP6
CDC27
FAM209A
MFF
PLPP6
SERP1
SERP2
SMCO4
TMEM179B
TREX1
UBE2J1
VAPA
Entrez ID
996
56287
HPRD ID
00304
16217
Ensembl ID
ENSG00000004897
ENSG00000169605
Uniprot IDs
B4DL80
G5EA36
P30260
A0A8I5KHR1
Q53YU7
Q9NS71
PDB IDs
3T1N
4RG6
4RG7
4RG9
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
6TNT
8PKP
8TAR
8TAU
9FGQ
9GAW
Enriched GO Terms of Interacting Partners
?
Anaphase-promoting Complex
Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Cell Division
Regulation Of Meiotic Cell Cycle
Regulation Of Cell Cycle
Protein Branched Polyubiquitination
Regulation Of Sister Chromatid Segregation
Regulation Of Reproductive Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Regulation Of Chromosome Segregation
Regulation Of Nuclear Division
Modification-dependent Protein Catabolic Process
Nucleoplasm
Regulation Of Chromosome Organization
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Metaphase/anaphase Transition Of Cell Cycle
Proteolysis Involved In Protein Catabolic Process
Regulation Of Mitotic Sister Chromatid Separation
Anaphase-promoting Complex Binding
Protein Polyubiquitination
Regulation Of Mitotic Nuclear Division
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Cycle Process
Regulation Of Chromosome Separation
Ubiquitin Ligase Activator Activity
Protein Ubiquitination
Post-translational Protein Modification
Regulation Of Mitotic Metaphase/anaphase Transition
Protein Modification By Small Protein Conjugation
Mitotic Checkpoint Complex
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Protein Modification Process
Catabolic Process
Protein K48-linked Ubiquitination
Proteolysis
Positive Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Cell Cycle
Cytosol
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Chromosome Separation
Cell Cycle Phase Transition
Endoplasmic Reticulum Membrane
Nitrate Transmembrane Transporter Activity
Membrane
Azurophil Granule Membrane
Endoplasmic Reticulum
Immune Complex Formation
Adenyl Deoxyribonucleotide Binding
Immune Response In Brain Or Nervous System
Response To Endoplasmic Reticulum Stress
Nuclear Inner Membrane
Isoprenoid Diphosphate Phosphatase Activity
Farnesyl Diphosphate Catabolic Process
Geranylgeranyl Diphosphate Catabolic Process
PH-gated Chloride Channel Activity
Nitrate Transmembrane Transport
Cellular Response To Type I Interferon
DNA Exonuclease Activity
Retrotransposition
Transposition
Endoplasmic Reticulum Unfolded Protein Response
Response To Unfolded Protein
FFAT Motif Binding
DNA Synthesis Involved In UV-damage Excision Repair
Geranyl Diphosphate Metabolic Process
Positive Regulation Of Neutrophil Activation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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