SRGAP3 and SMARCC2

Number of citations of the paper that reports this interaction (PubMedID 12368262)
41

Data Source:
HPRD (in vivo)

		SRGAP3	SMARCC2
Description		SLIT-ROBO Rho GTPase activating protein 3	SWI/SNF related BAF chromatin remodeling complex subunit C2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Synapse Postsynapse	Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex
	Molecular Function	GTPase Activator Activity Protein Binding	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding
	Biological Process	Signal Transduction Nervous System Development Negative Regulation Of Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synapse Assembly	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		Inactivation of CDC42 and RAC1 CDC42 GTPase cycle RAC1 GTPase cycle	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Body fat percentage ( 31752434) Lead levels in blood ( 25820613) Rapid automised naming of letters ( 30741946)	Asthma ( 31619474) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: DISC1 DTNBP1 ENKD1 FASLG KDM1A PRMT6 RAC1 SMARCC2 SUV39H1 TNIK WASF1	27 interacting genes: ARRB2 ATXN1 ATXN1L BAZ1B CEBPA CSNK2A1 EWSR1 FUS GATA1 IFTAP ITCH ITSN1 KLF1 KRT27 MCPH1 NOVA1 PEX14 PHYHIP POLR2C RAB1B RBPMS RELB SP1 SRGAP3 TAF15 TERF1 USP7
Entrez ID		9901	6601
HPRD ID		12108	03437
Ensembl ID		ENSG00000196220	ENSG00000139613
Uniprot IDs		O43295	F8VXC8 Q8TAQ2
PDB IDs			6KAG 6LTH 6LTJ 7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Regulation Of Dendritic Spine Development Cytoskeleton Organization Cell Projection Morphogenesis Cell Projection Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Actin Cytoskeleton Organization Cell Projection Assembly Cerebral Cortex Radially Oriented Cell Migration Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Development Rac Protein Signal Transduction Regulation Of Cell Development Actin Filament-based Process Regulation Of Postsynapse Organization Histone H3 Methyltransferase Activity Regulation Of Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuroblast Proliferation Cerebral Cortex Cell Migration Actin Filament Polymerization Histone Methyltransferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Telencephalon Cell Migration Lamellipodium Organization Glutamatergic Synapse Regulation Of DNA Repair Regulation Of Neuroblast Proliferation Ciliary Base Forebrain Cell Migration Dendrite Morphogenesis Developmental Process Positive Regulation Of Neural Precursor Cell Proliferation Non-motile Cilium Assembly Cilium Assembly Neuron Projection Morphogenesis Chromatin Remodeling Establishment Of Organelle Localization Wnt Signaling Pathway Actin Polymerization Or Depolymerization Histone H2AR3 Methyltransferase Activity	Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process POZ Domain Binding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere DNA-templated Transcription Nucleus Identical Protein Binding MRNA 3'-UTR Binding Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Transcription Repressor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Adaptor Activity Regulation Of Chromosome Condensation Negative Regulation Of RNA Metabolic Process DNA Binding Myeloid Cell Apoptotic Process Macromolecule Biosynthetic Process Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Postsynapse Regulation Of Chromosome Organization Myeloid Cell Differentiation Rhythmic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Chromatin Binding Granulocyte Differentiation Memory Regulation Of Transcription By RNA Polymerase II
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