SRGAP3 and DTNBP1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		SRGAP3	DTNBP1
Description		SLIT-ROBO Rho GTPase activating protein 3	dystrobrevin binding protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Synapse Postsynapse	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Sarcoplasm Axon Growth Cone Midbody Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Asymmetric Synapse Melanosome Membrane Sarcolemma Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process	Signal Transduction Nervous System Development Negative Regulation Of Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Synapse Assembly	Kidney Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Receptor Internalization Blood Coagulation Memory Anterograde Axonal Transport Regulation Of Signal Transduction Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Actin Cytoskeleton Organization Neuron Projection Development Melanosome Organization Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Dendrite Morphogenesis Retina Development In Camera-type Eye Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Cilium Assembly Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Protein Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways		Inactivation of CDC42 and RAC1 CDC42 GTPase cycle RAC1 GTPase cycle	Golgi Associated Vesicle Biogenesis
Drugs
Diseases			Hermansky-Pudlak syndrome (HPS)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Body fat percentage ( 31752434) Lead levels in blood ( 25820613) Rapid automised naming of letters ( 30741946)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Corneal astigmatism ( 30306274) Femur bone mineral density x serum urate levels interaction ( 34046847) Liver enzyme levels (alkaline phosphatase) ( 33972514) Multiple myeloma ( 27363682) Serum alkaline phosphatase levels ( 33547301) Squamous cell carcinoma ( 31174203)
Interacting Genes		11 interacting genes: DISC1 DTNBP1 ENKD1 FASLG KDM1A PRMT6 RAC1 SMARCC2 SUV39H1 TNIK WASF1	51 interacting genes: ABI3 AKAP6 ARFIP2 BICRAL BLOC1S5 BLOC1S6 BRF1 CCDC146 CCNA2 CCND3 CMYA5 DCTN1 DGCR6L DRC12 DST DTNA DTNB ELOVL7 HAUS1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 KRT75 MACF1 NBEA NDN NECAB2 NUF2 OIP5 P4HA3 PSME3 RAB11A RBSN SDCBP SFR1 SHFL SNAPIN SRGAP3 SSC5D SYNE1 TNKS TRAF3IP1 TRIM2 TRIM27 TRIM9 VRK2 WASHC3 ZNF490
Entrez ID		9901	84062
HPRD ID		12108	06190
Ensembl ID		ENSG00000196220	ENSG00000047579
Uniprot IDs		O43295	A0A087WYP9 A0A0S2Z5U8 A6NFV8 D6RJC6 Q96EV8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Regulation Of Dendritic Spine Development Cytoskeleton Organization Cell Projection Morphogenesis Cell Projection Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Actin Cytoskeleton Organization Cell Projection Assembly Cerebral Cortex Radially Oriented Cell Migration Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Development Rac Protein Signal Transduction Regulation Of Cell Development Actin Filament-based Process Regulation Of Postsynapse Organization Histone H3 Methyltransferase Activity Regulation Of Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuroblast Proliferation Cerebral Cortex Cell Migration Actin Filament Polymerization Histone Methyltransferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Telencephalon Cell Migration Lamellipodium Organization Glutamatergic Synapse Regulation Of DNA Repair Regulation Of Neuroblast Proliferation Ciliary Base Forebrain Cell Migration Dendrite Morphogenesis Developmental Process Positive Regulation Of Neural Precursor Cell Proliferation Non-motile Cilium Assembly Cilium Assembly Neuron Projection Morphogenesis Chromatin Remodeling Establishment Of Organelle Localization Wnt Signaling Pathway Actin Polymerization Or Depolymerization Histone H2AR3 Methyltransferase Activity	Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Axonal Transport Microtubule-based Movement Transport Along Microtubule BLOC-1 Complex Anterograde Synaptic Vesicle Transport Axo-dendritic Transport Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Microtubule-based Transport Establishment Of Vesicle Localization Axon Cytoplasm Microvesicle Vesicle Localization Endosome To Melanosome Transport Plasma Membrane Bounded Cell Projection Organization Synaptic Vesicle Transport Intracellular Transport Melanosome Organization Cellular Localization Nuclear Envelope Pigment Granule Organization Cell Projection Organization Anterograde Axonal Transport Organelle Organization Vesicle Transport Along Microtubule Cytoskeleton Organization Cytoplasm Microtubule Binding Nuclear Membrane Vesicle Cytoskeletal Trafficking Centrosome Establishment Of Protein Localization Cytoskeleton Secretion Of Lysosomal Enzymes Protein Transmembrane Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Positive Regulation Of Pigment Cell Differentiation Spindle Pole Plasma Membrane Bounded Cell Projection Assembly Neuron Projection Development Organelle Transport Along Microtubule Regulation Of Actin Nucleation Cell Projection Assembly Protein Transport
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