TBC1D4 and NFAT5

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		TBC1D4	NFAT5
Description		TBC1 domain family member 4	nuclear factor of activated T cells 5
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Vesicle	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus	DNA-templated Transcription Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Response To Stress DNA Damage Response Signal Transduction Positive Regulation Of Gene Expression Calcineurin-NFAT Signaling Cascade Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II R-loop Processing Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Cytokine Stimulus Cellular Hyperosmotic Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Eosinophil count ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Adult body size ( 32376654) Blood osmolality (transformed sodium) ( 28360221) Blood urea nitrogen levels ( 31152163 29403010) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Chloride levels ( 29403010) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31015462 30604766) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Hyperuricemia ( 29124443) Intralaminar thalamic nuclei volume ( 34006833) Menarche (age at onset) ( 21102462 27182965 25231870) Metabolic syndrome ( 31589552) Pulse pressure ( 27841878 28135244) Self-reported risk-taking behaviour ( 30181555) Serum uric acid levels ( 30993211 29124443) Sjögren's syndrome ( 28076899) Smoking initiation (ever regular vs never regular) ( 30679032) Sodium levels ( 29403010) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458 30297969) Urate levels ( 31985003 23263486)
Interacting Genes		16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1	5 interacting genes: ABL1 FOXP3 NFE2L2 TBC1D4 TRIM14
Entrez ID		9882	10725
HPRD ID		18164	05272
Ensembl ID		ENSG00000136111	ENSG00000102908
Uniprot IDs		O60343	O94916
PDB IDs		3QYB 7NIX	1IMH
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Macromolecule Biosynthetic Process Phosphorylation-dependent Protein Binding Positive Regulation Of RNA Biosynthetic Process TOR Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Chromatin Organization Positive Regulation Of RNA Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Protein Localization To Organelle Positive Regulation Of Cell-cell Adhesion Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of TOR Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Mitotic Spindle Orientation Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Cytoskeleton Organization Transposable Element Silencing Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nucleoplasm Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of TRNA Methylation Cis-trans Isomerase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitotic Cell Cycle Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Constitutive Heterochromatin Formation Establishment Of Spindle Localization Regulation Of Intracellular Signal Transduction	Regulation Of Hematopoietic Stem Cell Differentiation Cellular Response To Fluid Shear Stress B Cell Homeostasis Regulation Of Hematopoietic Progenitor Cell Differentiation Response To Fluid Shear Stress Negative Regulation Of Endothelial Cell Apoptotic Process T Cell Proliferation Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Apoptotic Process Regulation Of Stem Cell Differentiation Alpha-beta T Cell Differentiation Leukocyte Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Interleukin-2 Production Negative Regulation Of DNA Recombination Lymphocyte Homeostasis Protein Localization To Cytoplasmic Microtubule Plus-end B Cell Activation Involved In Immune Response Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of Peripheral T Cell Tolerance Induction Transitional One Stage B Cell Differentiation Alpha-beta T Cell Activation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Type II Interferon Production Podocyte Apoptotic Process DN4 Thymocyte Differentiation T Cell Receptor Signaling Pathway Response To Hydrogen Peroxide Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Lymphocyte Proliferation Cellular Response To Reactive Oxygen Species Inflammatory Response Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Establishment Of Endothelial Blood-brain Barrier Regulation Of Tolerance Induction Dependent Upon Immune Response CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment Mononuclear Cell Proliferation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Neuron Projection Development Positive Regulation Of RNA Biosynthetic Process T Cell Differentiation Response To Reactive Oxygen Species Microspike Assembly Nicotinate-nucleotide Adenylyltransferase Activity Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway B-1 B Cell Homeostasis Negative Regulation Of DNA Metabolic Process
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