TBC1D4 and RESF1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		TBC1D4	RESF1
Description		TBC1 domain family member 4	retroelement silencing factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Vesicle	Nucleus
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding Histone Binding Histone Methyltransferase Binding
	Biological Process	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus	Transposable Element Silencing By Heterochromatin Formation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Eosinophil count ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1	10 interacting genes: EXOC1 GABARAP GABARAPL1 GABARAPL2 KRT36 KRT86 MAP1LC3A MAP1LC3C MDM2 TBC1D4
Entrez ID		9882	55196
HPRD ID		18164	07691
Ensembl ID		ENSG00000136111	ENSG00000174718
Uniprot IDs		O60343	Q9HCM1
PDB IDs		3QYB 7NIX
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Macromolecule Biosynthetic Process Phosphorylation-dependent Protein Binding Positive Regulation Of RNA Biosynthetic Process TOR Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Chromatin Organization Positive Regulation Of RNA Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Protein Localization To Organelle Positive Regulation Of Cell-cell Adhesion Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of TOR Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Mitotic Spindle Orientation Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Cytoskeleton Organization Transposable Element Silencing Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nucleoplasm Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of TRNA Methylation Cis-trans Isomerase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitotic Cell Cycle Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Constitutive Heterochromatin Formation Establishment Of Spindle Localization Regulation Of Intracellular Signal Transduction	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Cellular Response To Nutrient Levels Phospholipid Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Response To Starvation Response To Nutrient Levels GABA Receptor Binding Autophagy Beta-tubulin Binding Cytosol Organelle Assembly Microtubule Protein-containing Complex Organization Cytoplasmic Vesicle Cellular Response To Stress Organelle Organization Response To Iron Ion Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Organelle Membrane Microtubule Binding Endomembrane System Establishment Of Protein Localization Response To Stress Structural Constituent Of Skin Epidermis Response To Formaldehyde Cellular Response To Vitamin B1 Cellular Response To Hydrogen Peroxide Cytoskeleton Intermediate Filament Organization Cellular Component Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Keratin Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Response To Hydrogen Peroxide
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