TBC1D4 and ZMIZ1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		TBC1D4	ZMIZ1
Description		TBC1 domain family member 4	zinc finger MIZ-type containing 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Vesicle	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding	Transcription Coactivator Activity Zinc Ion Binding SMAD Binding Metal Ion Binding SUMO Ligase Activity
	Biological Process	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus	Vasculogenesis In Utero Embryonic Development Heart Morphogenesis Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Vitellogenesis Protein Sumoylation Pyramidal Neuron Migration To Cerebral Cortex Androgen Receptor Signaling Pathway Positive Regulation Of T Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Developmental Growth Artery Morphogenesis SMAD Protein Signal Transduction Cellular Senescence
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Eosinophil count ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	A body shape index ( 34021172) Adult body size ( 32376654) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 20351715) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 20453838 23535729) Brown vs. black hair color ( 30531825) Celiac disease ( 25920553 30572963 22057235 20190752) Ceramide levels (C24:0) ( 32489964) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cobalt levels ( 26025379) Colorectal cancer ( 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 28067908 21102463 25489960) Crohn's disease and psoriasis ( 22482804) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Height ( 31562340 25429064 25282103 23563607) High density lipoprotein cholesterol levels ( 31928498) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Marginal zone lymphoma or multiple sclerosis ( 31407831) Mean platelet volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 19525953 31604244 21833088 24076602 22190364) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Pediatric autoimmune diseases ( 26301688) Platelet distribution width ( 32888494 27863252) PR interval ( 32439900) Prostate cancer ( 31562322) Psoriasis ( 25854761 23143594) Psoriasis vulgaris ( 26626624) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Takayasu arteritis ( 33308445) TPE interval (resting) ( 32386560) Triiodothyronine/thyroxine ratio ( 30824882) Type 2 diabetes ( 32499647 28869590 31118516 30718926 30297969 30054458 29358691 26818947 24509480 22885922) Urate levels ( 31578528) Vitiligo ( 20526339) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1	5 interacting genes: AR CACHD1 CNTNAP2 PIAS3 TBC1D4
Entrez ID		9882	57178
HPRD ID		18164	12115
Ensembl ID		ENSG00000136111	ENSG00000108175
Uniprot IDs		O60343	A0JLS3 Q9ULJ6
PDB IDs		3QYB 7NIX	5AIZ
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Macromolecule Biosynthetic Process Phosphorylation-dependent Protein Binding Positive Regulation Of RNA Biosynthetic Process TOR Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Chromatin Organization Positive Regulation Of RNA Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Protein Localization To Organelle Positive Regulation Of Cell-cell Adhesion Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of TOR Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Mitotic Spindle Orientation Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Cytoskeleton Organization Transposable Element Silencing Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nucleoplasm Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of TRNA Methylation Cis-trans Isomerase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitotic Cell Cycle Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Constitutive Heterochromatin Formation Establishment Of Spindle Localization Regulation Of Intracellular Signal Transduction	Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Induction Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Vesicle Fusion Clustering Of Voltage-gated Potassium Channels Limbic System Development Superior Temporal Gyrus Development Protein Localization To Juxtaparanode Region Of Axon Genitalia Morphogenesis Androgen Binding RNA Polymerase II General Transcription Initiation Factor Binding Lateral Sprouting From An Epithelium Male Sex Determination Leydig Cell Differentiation Cellular Response To Testosterone Stimulus Estrogen Response Element Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Prostatic Bud Formation Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Differentiation Involved In Prostate Gland Development Cellular Response To Hormone Stimulus Negative Regulation Of Protein Sumoylation SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Juxtaparanode Region Of Axon Paranode Region Of Axon Vocal Learning Auditory Behavior Prepulse Inhibition Neuronal Ion Channel Clustering Axolemma Thalamus Development Observational Learning Protein Localization To Axon Regulation Of Gap Junction Assembly Paranodal Junction Positive Regulation Of Gap Junction Assembly Morphogenesis Of An Epithelial Fold Striatum Development Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Mechanosensory Behavior
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