TBC1D4 and U2SURP

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)

		TBC1D4	U2SURP
Gene Name		TBC1 domain family, member 4	U2 snRNP-associated SURP domain containing
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	Rab GTPase Activator Activity	Nucleotide Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Positive Regulation Of Rab GTPase Activity Cellular Response To Insulin Stimulus Membrane Organization	RNA Processing
Pathways		Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Heart failure ( 20445134)
Protein-Protein Interactions		14 interactors: AKT1 CDK5RAP2 EP400 FAM208A KIAA1551 NAV1 NFAT5 PIN1 RBM12 TET2 TOPBP1 U2SURP YWHAG ZMIZ1	7 interactors: CTNNBL1 DDX42 PRPF40A RBM17 TBC1D4 TERT TRA2A
Entrez ID		9882	23350
HPRD ID		18164	19056
Ensembl ID		ENSG00000136111	ENSG00000163714
Uniprot IDs		O60343	O15042
PDB IDs		3QYB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition Microtubule Bundle Formation Positive Regulation Of Mitochondrion Organization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process 5-methylcytosine Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Organelle Organization Peptidyl-amino Acid Modification Negative Regulation Of Phosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vitellogenesis Regulation Of Cell Cycle Process Organelle Organization G2/M Transition Of Mitotic Cell Cycle Cytosine Metabolic Process Regulation Of Neuron Differentiation Liver Morphogenesis Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Centriole Replication Hematopoietic Stem Cell Homeostasis Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of MAPK Cascade Response To UV-A Activation-induced Cell Death Of T Cells Oxidative DNA Demethylation Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Regulation Of Neurogenesis Myeloid Progenitor Cell Differentiation Cytoplasm Organization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Generation Of Neurons Cellular Response To Insulin Stimulus Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity	RNA Processing RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated RNA Metabolic Process Telomere Formation Via Telomerase Age-dependent Telomere Shortening Gene Expression Telomere Maintenance Via Telomere Shortening Telomere Assembly Negative Regulation Of Vesicle Fusion Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference Nucleobase-containing Compound Metabolic Process RNA Interference Alternative MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Replicative Senescence Cellular Nitrogen Compound Metabolic Process RNA-dependent DNA Replication Regulation Of Gene Silencing DNA Strand Elongation Nitrogen Compound Metabolic Process Telomere Maintenance Via Telomere Lengthening Cellular Response To DsRNA Regulation Of Vesicle Fusion Somatic Diversification Of Immunoglobulins Posttranscriptional Gene Silencing
Tagcloud ?		amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Difference) ?		amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Intersection) ?