TBC1D4 and TASOR

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		TBC1D4	TASOR
Description		TBC1 domain family member 4	transcription activation suppressor
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Vesicle	Heterochromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	GTPase Activator Activity Protein Binding	Chromatin Binding RNA Binding Protein Binding
	Biological Process	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus	Anterior/posterior Axis Specification, Embryo Negative Regulation Of Gene Expression, Epigenetic Mesodermal To Mesenchymal Transition Involved In Gastrulation Protein Localization To Heterochromatin Constitutive Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Eosinophil count ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Appendicular lean mass ( 33097823)
Interacting Genes		16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1	5 interacting genes: AP2M1 RB1 RNF10 TBC1D4 TOM1L1
Entrez ID		9882	23272
HPRD ID		18164	10183
Ensembl ID		ENSG00000136111	ENSG00000163946
Uniprot IDs		O60343	Q9UK61
PDB IDs		3QYB 7NIX	6SWG 6TL1
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Macromolecule Biosynthetic Process Phosphorylation-dependent Protein Binding Positive Regulation Of RNA Biosynthetic Process TOR Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Chromatin Organization Positive Regulation Of RNA Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Protein Localization To Organelle Positive Regulation Of Cell-cell Adhesion Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of TOR Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Mitotic Spindle Orientation Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Cytoskeleton Organization Transposable Element Silencing Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nucleoplasm Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of TRNA Methylation Cis-trans Isomerase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitotic Cell Cycle Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Constitutive Heterochromatin Formation Establishment Of Spindle Localization Regulation Of Intracellular Signal Transduction	Negative Regulation Of Glial Cell Proliferation Disordered Domain Specific Binding Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cellular Component Organization Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Regulation Of Gliogenesis Negative Regulation Of Cell Cycle Process Negative Regulation Of Myofibroblast Differentiation Sister Chromatid Biorientation Negative Regulation Of Nervous System Development Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Regulation Of Mitotic Nuclear Division Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Enucleate Erythrocyte Differentiation Cellular Response To Insulin Stimulus Glial Cell Apoptotic Process Regulation Of Nuclear Division Negative Regulation Of Mitotic Cell Cycle Response To Insulin Negative Regulation Of Cell Development Rb-E2F Complex Regulation Of Protein Kinase Activity Regulation Of Centromere Complex Assembly Cellular Response To Peptide Hormone Stimulus Regulation Of Collagen Fibril Organization Cyclin/CDK Positive Transcription Elongation Factor Complex Regulation Of Kinase Activity Chromatin Lock Complex Importin-alpha Family Protein Binding Negative Regulation Of Neurogenesis Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vesicle Fusion Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Protein Autophosphorylation AP-2 Adaptor Complex Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Organelle Organization Response To Peptide Hormone Clathrin Adaptor Complex Cellular Response To Hormone Stimulus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?