TBC1D4 and TET2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)

		TBC1D4	TET2
Description		TBC1 domain family member 4	tet methylcytosine dioxygenase 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Vesicle	Nucleus Nucleoplasm Chromosome
	Molecular Function	GTPase Activator Activity Protein Binding	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Metal Ion Binding Dioxygenase Activity DNA 5-methylcytosine Dioxygenase Activity
	Biological Process	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus	Leukocyte Differentiation Chromatin Organization Protein O-linked Glycosylation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Differentiation Epigenetic Regulation Of Gene Expression Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane	TET1,2,3 and TDG demethylate DNA Specification of primordial germ cells
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Eosinophil count ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 27863252 32888494 29403010) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	A body shape index ( 34021172) Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Chronic obstructive pulmonary disease ( 33909500 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) Fasting insulin ( 34059833) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte count ( 29403010 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 24076602 31604244) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of white cells ( 32888494 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Platelet count ( 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Response to esketamine in treatment resistant depression ( 32724131) Self-reported risk-taking behaviour ( 30271922) Serum alkaline phosphatase levels ( 33547301) Tonsillectomy ( 27182965 28928442) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Western dietary pattern ( 28644415)
Interacting Genes		16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1	20 interacting genes: DCAF1 ECD EIF2B2 HLF HOXB9 KEAP1 MED1 MNAT1 OGT PHC1 PKNOX1 RAI1 SMAD1 STAT5A TBC1D4 TFEC VPS26C VPS72 ZCCHC14 ZNF207
Entrez ID		9882	54790
HPRD ID		18164	07876
Ensembl ID		ENSG00000136111	ENSG00000168769
Uniprot IDs		O60343	A0A158SIU0 Q6N021
PDB IDs		3QYB 7NIX	4NM6 5D9Y 5DEU 7NE3 7NE6
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Macromolecule Biosynthetic Process Phosphorylation-dependent Protein Binding Positive Regulation Of RNA Biosynthetic Process TOR Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Chromatin Organization Positive Regulation Of RNA Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Protein Localization To Organelle Positive Regulation Of Cell-cell Adhesion Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of TOR Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Mitotic Spindle Orientation Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Cytoskeleton Organization Transposable Element Silencing Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nucleoplasm Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of TRNA Methylation Cis-trans Isomerase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitotic Cell Cycle Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Constitutive Heterochromatin Formation Establishment Of Spindle Localization Regulation Of Intracellular Signal Transduction	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Macromolecule Biosynthetic Process Chromatin Rhythmic Process Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Response To Peptide Hormone Histone Acetyltransferase Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Mononuclear Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Response To Hormone RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Epithelial Cell Differentiation DNA-binding Transcription Factor Activity Mammary Gland Development Leukocyte Differentiation Nuclear Estrogen Receptor Binding Developmental Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Cell Cycle Hemopoiesis Lactation
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