TBC1D4 and TET2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)

		TBC1D4	TET2
Gene Name		TBC1 domain family, member 4	tet methylcytosine dioxygenase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Rab GTPase Activator Activity	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity
	Biological Process	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Positive Regulation Of Rab GTPase Activity Cellular Response To Insulin Stimulus Membrane Organization	Kidney Development Myeloid Progenitor Cell Differentiation 5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Post-embryonic Development Gene Expression Cytosine Metabolic Process Hemoglobin Metabolic Process Myeloid Cell Differentiation Oxidative DNA Demethylation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Hematopoietic Stem Cell Homeostasis Liver Morphogenesis DNA Demethylation Histone H3-K4 Trimethylation
Pathways		Translocation of GLUT4 to the plasma membrane	TET1,2,3 and TDG demethylate DNA Epigenetic regulation of gene expression
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Heart failure ( 20445134)	Breast cancer ( 23535729) Height ( 20881960) Immune response to anthrax vaccine ( 22658931) Prostate cancer ( 19767753) Pulmonary function ( 21946350)
Protein-Protein Interactions		14 interactors: AKT1 CDK5RAP2 EP400 FAM208A KIAA1551 NAV1 NFAT5 PIN1 RBM12 TET2 TOPBP1 U2SURP YWHAG ZMIZ1	2 interactors: OGT TBC1D4
Entrez ID		9882	54790
HPRD ID		18164	07876
Ensembl ID		ENSG00000136111	ENSG00000168769
Uniprot IDs		O60343	Q6N021
PDB IDs		3QYB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition Microtubule Bundle Formation Positive Regulation Of Mitochondrion Organization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process 5-methylcytosine Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Organelle Organization Peptidyl-amino Acid Modification Negative Regulation Of Phosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vitellogenesis Regulation Of Cell Cycle Process Organelle Organization G2/M Transition Of Mitotic Cell Cycle Cytosine Metabolic Process Regulation Of Neuron Differentiation Liver Morphogenesis Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Centriole Replication Hematopoietic Stem Cell Homeostasis Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of MAPK Cascade Response To UV-A Activation-induced Cell Death Of T Cells Oxidative DNA Demethylation Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Regulation Of Neurogenesis Myeloid Progenitor Cell Differentiation Cytoplasm Organization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Generation Of Neurons Cellular Response To Insulin Stimulus Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity	Response To Insulin Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Response To Peptide Hormone Response To Peptide Negative Regulation Of Vesicle Fusion Positive Regulation Of Granulocyte Differentiation Regulation Of Ras Protein Signal Transduction Positive Regulation Of Histone H3-K27 Methylation Regulation Of Small GTPase Mediated Signal Transduction Histone H3-K4 Trimethylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Regulation Of Histone H3-K27 Methylation Histone H4-K16 Acetylation Response To Organonitrogen Compound Positive Regulation Of Histone H3-K4 Methylation Regulation Of Organelle Organization Response To Hormone Regulation Of Histone H3-K4 Methylation Regulation Of Glycolytic Process Peptidyl-lysine Trimethylation Histone H3-K4 Methylation Regulation Of Rac Protein Signal Transduction Regulation Of Vesicle Fusion Positive Regulation Of Histone Methylation Regulation Of Gluconeogenesis Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Catalytic Activity Histone H4 Acetylation Regulation Of Histone Methylation Regulation Of Insulin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Retinoic Acid Positive Regulation Of Histone Modification Regulation Of Generation Of Precursor Metabolites And Energy Cellular Glucose Homeostasis Cellular Response To Organic Substance Positive Regulation Of Myeloid Cell Differentiation Circadian Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Cellular Response To Insulin Stimulus Protein O-linked Glycosylation Histone Lysine Methylation Peptidyl-lysine Methylation Negative Regulation Of Protein Ubiquitination Regulation Of Glucose Metabolic Process Regulation Of Myeloid Leukocyte Differentiation Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation
Tagcloud ?		amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand	abstract advancements ascribed asxl1 attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating idh2 incurable optimize overview profoundly renders sf3b1 sibling spite stratify transplant video wider
Tagcloud (Difference) ?		amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand	abstract advancements ascribed asxl1 attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating idh2 incurable optimize overview profoundly renders sf3b1 sibling spite stratify transplant video wider
Tagcloud (Intersection) ?