ELMO1 and RHOG

Number of citations of the paper that reports this interaction (PMID 12879077)
76

Data Source:
HPRD (in vivo)

		ELMO1	RHOG
Gene Name		engulfment and cell motility 1	ras homolog family member G
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane	Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Protein Binding SH3 Domain Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Movement Of Cell Or Subcellular Component Viral Process Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Positive Regulation Of Cell Proliferation Rac Protein Signal Transduction Actin Cytoskeleton Organization Platelet Activation Activation Of Rac GTPase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Ruffle Assembly
Pathways		Signaling by VEGF HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System Nef and signal transduction	Signaling by GPCR Axon guidance Semaphorin interactions Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Breast size ( 22747683) Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Type 2 diabetes nephropathy ( 17653210)
Protein-Protein Interactions		6 interactors: DOCK1 FGD1 HCK RHOG TRIM54 ZNF398	19 interactors: ARHGDIA ARHGDIG DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3
Entrez ID		9844	391
HPRD ID		12102	01537
Ensembl ID		ENSG00000155849	ENSG00000177105
Uniprot IDs		A4D1X5 Q92556	P84095 Q6ICQ8
PDB IDs		2RQR 2VSZ 3A98
Enriched GO Terms of Interacting Partners?		Respiratory Burst After Phagocytosis Small GTPase Mediated Signal Transduction Integrin-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Migration Involved In Immune Response Positive Regulation Of GTPase Activity Regulation Of Cellular Component Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of GTPase Activity Regulation Of Cell Shape Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Respiratory Burst Involved In Defense Response Positive Regulation Of Hydrolase Activity Positive Regulation Of Rho GTPase Activity Regulation Of Podosome Assembly Phagocytosis Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Organization Signal Transduction Locomotion Regulation Of Rho Protein Signal Transduction Respiratory Burst Developmental Process Activation Of Rac GTPase Activity Phagocytosis, Engulfment Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Actin Cytoskeleton Reorganization Axon Guidance Cell Communication Movement Of Cell Or Subcellular Component Blood Coagulation Positive Regulation Of Catalytic Activity Regulation Of Ruffle Assembly Membrane Invagination Filopodium Assembly Hemostasis Positive Regulation Of Ras GTPase Activity Cell Differentiation Positive Regulation Of Metabolic Process Rac Protein Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane	Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Phagocytosis Signal Transduction Apoptotic Process Programmed Cell Death Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rho GTPase Activity Cellular Response To Stimulus Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Signal Transduction Response To Stress Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Chemotaxis Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		ahsa2 cd coeliac ddx59 egenes eprobes eqtl eqtls esnps harbour il18rap implies nominal nsf overlapped park7 pbmc rs12727642 rs13003464 rs2074404 rs2298428 rs296547 rs6974491 rs842647 rs917997 snps thymic thymus ube2l3	adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2
Tagcloud (Difference) ?		ahsa2 cd coeliac ddx59 egenes eprobes eqtl eqtls esnps harbour il18rap implies nominal nsf overlapped park7 pbmc rs12727642 rs13003464 rs2074404 rs2298428 rs296547 rs6974491 rs842647 rs917997 snps thymic thymus ube2l3	adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2
Tagcloud (Intersection) ?