ELMO1

Gene Name		engulfment and cell motility 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	Protein Binding SH3 Domain Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Movement Of Cell Or Subcellular Component Viral Process Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus
Pathways		Signaling by VEGF HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System Nef and signal transduction
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Breast size ( 22747683) Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Type 2 diabetes nephropathy ( 17653210)
Protein-protein Interactions		6 interactors: DOCK1 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		9844
HPRD ID		12102
Ensembl ID		ENSG00000155849
Uniprot IDs		A4D1X5 Q92556
PDB IDs		2RQR 2VSZ 3A98
Enriched GO Terms of Interacting Partners?		Respiratory Burst After Phagocytosis Small GTPase Mediated Signal Transduction Integrin-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Migration Involved In Immune Response Positive Regulation Of GTPase Activity Regulation Of Cellular Component Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of GTPase Activity Regulation Of Cell Shape Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Respiratory Burst Involved In Defense Response Positive Regulation Of Hydrolase Activity Positive Regulation Of Rho GTPase Activity Regulation Of Podosome Assembly Phagocytosis Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Organization Signal Transduction Locomotion Regulation Of Rho Protein Signal Transduction Respiratory Burst Developmental Process Activation Of Rac GTPase Activity Phagocytosis, Engulfment Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Actin Cytoskeleton Reorganization Axon Guidance Cell Communication Movement Of Cell Or Subcellular Component Blood Coagulation Positive Regulation Of Catalytic Activity Regulation Of Ruffle Assembly Membrane Invagination Filopodium Assembly Hemostasis Positive Regulation Of Ras GTPase Activity Cell Differentiation Positive Regulation Of Metabolic Process Rac Protein Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Tagcloud ?		ahsa2 cd coeliac ddx59 egenes eprobes eqtl eqtls esnps harbour il18rap implies nominal nsf overlapped park7 pbmc rs12727642 rs13003464 rs2074404 rs2298428 rs296547 rs6974491 rs842647 rs917997 snps thymic thymus ube2l3