ELMO1 and FGD1

Number of citations of the paper that reports this interaction (PMID 12134158)
109

Data Source:
HPRD (in vivo)

		ELMO1	FGD1
Gene Name		engulfment and cell motility 1	FYVE, RhoGEF and PH domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium
	Molecular Function	Protein Binding SH3 Domain Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Movement Of Cell Or Subcellular Component Viral Process Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus	Cytoskeleton Organization Signal Transduction Small GTPase Mediated Signal Transduction Multicellular Organismal Development Regulation Of Cell Shape Organ Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Cdc42 GTPase Activity Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Signaling by VEGF HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System Nef and signal transduction	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Breast size ( 22747683) Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Type 2 diabetes nephropathy ( 17653210)
Protein-Protein Interactions		6 interactors: DOCK1 FGD1 HCK RHOG TRIM54 ZNF398	4 interactors: AOC1 CDC42 CTTN ELMO1
Entrez ID		9844	2245
HPRD ID		12102	02373
Ensembl ID		ENSG00000155849	ENSG00000102302
Uniprot IDs		A4D1X5 Q92556	P98174
PDB IDs		2RQR 2VSZ 3A98
Enriched GO Terms of Interacting Partners?		Respiratory Burst After Phagocytosis Small GTPase Mediated Signal Transduction Integrin-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Migration Involved In Immune Response Positive Regulation Of GTPase Activity Regulation Of Cellular Component Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of GTPase Activity Regulation Of Cell Shape Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Respiratory Burst Involved In Defense Response Positive Regulation Of Hydrolase Activity Positive Regulation Of Rho GTPase Activity Regulation Of Podosome Assembly Phagocytosis Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Organization Signal Transduction Locomotion Regulation Of Rho Protein Signal Transduction Respiratory Burst Developmental Process Activation Of Rac GTPase Activity Phagocytosis, Engulfment Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Actin Cytoskeleton Reorganization Axon Guidance Cell Communication Movement Of Cell Or Subcellular Component Blood Coagulation Positive Regulation Of Catalytic Activity Regulation Of Ruffle Assembly Membrane Invagination Filopodium Assembly Hemostasis Positive Regulation Of Ras GTPase Activity Cell Differentiation Positive Regulation Of Metabolic Process Rac Protein Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane	Actin Cytoskeleton Organization Actin Filament-based Process Adherens Junction Organization Endocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Copper Ion Starvation Cellular Response To Azide Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Hair Follicle Cell Proliferation Cytoskeleton Organization Cell-cell Junction Organization Actin Filament Branching Submandibular Salivary Gland Formation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Phagocytosis Fc Receptor Signaling Pathway Cellular Response To Heparin Immune Response-activating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Cell Projection Assembly Response To Heparin Establishment Of Golgi Localization Cellular Response To Copper Ion Actin Filament Organization Movement Of Cell Or Subcellular Component Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Metalloenzyme Activity Regulation Of Protein Complex Assembly Dendritic Spine Maintenance Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Histamine Regulation Of Protein Heterodimerization Activity Keratinocyte Development Substrate-dependent Cell Migration, Cell Extension Regulation Of Synapse Structural Plasticity Response To Histamine Transport Positive Regulation Of Pseudopodium Assembly Nuclear Migration Cardiac Conduction System Development Phagocytosis, Engulfment Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Golgi Localization Regulation Of Cell Projection Organization
Tagcloud ?		ahsa2 cd coeliac ddx59 egenes eprobes eqtl eqtls esnps harbour il18rap implies nominal nsf overlapped park7 pbmc rs12727642 rs13003464 rs2074404 rs2298428 rs296547 rs6974491 rs842647 rs917997 snps thymic thymus ube2l3	apo bend butterfly catalysis charged citrate coenzyme competitive crystallography facilitates flavin g6p helps identifies isoalloxazine microorganisms moiety mycobacteria nitroimidazopyran occupies packs persistence phosphate pocket prodrug replicating resolutions shared
Tagcloud (Difference) ?		ahsa2 cd coeliac ddx59 egenes eprobes eqtl eqtls esnps harbour il18rap implies nominal nsf overlapped park7 pbmc rs12727642 rs13003464 rs2074404 rs2298428 rs296547 rs6974491 rs842647 rs917997 snps thymic thymus ube2l3	apo bend butterfly catalysis charged citrate coenzyme competitive crystallography facilitates flavin g6p helps identifies isoalloxazine microorganisms moiety mycobacteria nitroimidazopyran occupies packs persistence phosphate pocket prodrug replicating resolutions shared
Tagcloud (Intersection) ?