ELMO1 and DOCK1

Number of citations of the paper that reports this interaction (PMID 12134158)
109

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		ELMO1	DOCK1
Gene Name		engulfment and cell motility 1	dedicator of cytokinesis 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding SH3 Domain Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Movement Of Cell Or Subcellular Component Viral Process Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus	Hematopoietic Progenitor Cell Differentiation Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of GTPase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		Signaling by VEGF HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System Nef and signal transduction	Axon guidance Signaling by VEGF DCC mediated attractive signaling Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Netrin-1 signaling VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Breast size ( 22747683) Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Type 2 diabetes nephropathy ( 17653210)	Apolipoprotein Levels ( 23031429)
Protein-Protein Interactions		6 interactors: DOCK1 FGD1 HCK RHOG TRIM54 ZNF398	8 interactors: BCAR1 CRK ELMO1 ELMO2 NCK2 RAC1 RHOG WASF2
Entrez ID		9844	1793
HPRD ID		12102	03240
Ensembl ID		ENSG00000155849	ENSG00000150760
Uniprot IDs		A4D1X5 Q92556	Q14185
PDB IDs		2RQR 2VSZ 3A98	3L4C
Enriched GO Terms of Interacting Partners?		Respiratory Burst After Phagocytosis Small GTPase Mediated Signal Transduction Integrin-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Migration Involved In Immune Response Positive Regulation Of GTPase Activity Regulation Of Cellular Component Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of GTPase Activity Regulation Of Cell Shape Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Respiratory Burst Involved In Defense Response Positive Regulation Of Hydrolase Activity Positive Regulation Of Rho GTPase Activity Regulation Of Podosome Assembly Phagocytosis Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Organization Signal Transduction Locomotion Regulation Of Rho Protein Signal Transduction Respiratory Burst Developmental Process Activation Of Rac GTPase Activity Phagocytosis, Engulfment Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Actin Cytoskeleton Reorganization Axon Guidance Cell Communication Movement Of Cell Or Subcellular Component Blood Coagulation Positive Regulation Of Catalytic Activity Regulation Of Ruffle Assembly Membrane Invagination Filopodium Assembly Hemostasis Positive Regulation Of Ras GTPase Activity Cell Differentiation Positive Regulation Of Metabolic Process Rac Protein Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane	Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Actin Cytoskeleton Organization Phagocytosis Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Actin Filament-based Process Regulation Of Immune System Process Rac Protein Signal Transduction Movement Of Cell Or Subcellular Component Cell Migration Regulation Of Immune Response Cell Motility Cell Chemotaxis Platelet Activation Cytoskeleton Organization Lamellipodium Assembly Immune System Process Lamellipodium Organization Chemotaxis Locomotion Endocytosis Cell Activation Innate Immune Response Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Blood Coagulation Regulation Of Cell Projection Assembly Hemostasis Regulation Of Cellular Component Organization Phagocytosis, Engulfment Response To Stress Positive Regulation Of Lamellipodium Assembly Signaling Cell Communication Regulation Of Cytoskeleton Organization Membrane Invagination Positive Regulation Of Lamellipodium Organization Regulation Of Body Fluid Levels
Tagcloud ?		ahsa2 cd coeliac ddx59 egenes eprobes eqtl eqtls esnps harbour il18rap implies nominal nsf overlapped park7 pbmc rs12727642 rs13003464 rs2074404 rs2298428 rs296547 rs6974491 rs842647 rs917997 snps thymic thymus ube2l3	adhesion adhesions cadherin canine completion contacts coordinate coordination darby dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected
Tagcloud (Difference) ?		ahsa2 cd coeliac ddx59 egenes eprobes eqtl eqtls esnps harbour il18rap implies nominal nsf overlapped park7 pbmc rs12727642 rs13003464 rs2074404 rs2298428 rs296547 rs6974491 rs842647 rs917997 snps thymic thymus ube2l3	adhesion adhesions cadherin canine completion contacts coordinate coordination darby dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected
Tagcloud (Intersection) ?