TSC22D2 and REV1

Number of citations of the paper that reports this interaction (PubMedID 27337956)
0

Data Source:
BioGRID (two hybrid)

		TSC22D2	REV1
Description		TSC22 domain family member 2	REV1 DNA directed polymerase
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm
	Molecular Function	Protein Binding	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Deoxycytidyl Transferase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Cell Cycle	DNA Metabolic Process DNA Replication DNA Repair DNA Damage Response Response To UV Error-prone Translesion Synthesis Error-free Translesion Synthesis DNA Biosynthetic Process
Pathways			Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 30297969 30054458) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 21926972)
Interacting Genes		43 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 USP7 WNK3 ZMYM2 ZNF143 ZNF251	13 interacting genes: CLK1 FAAP20 FHL2 MAD2L2 POLD3 POLDIP2 POLH POLI POLK POLL REV3L TSC22D2 UBC
Entrez ID		9819	51455
HPRD ID		11101	16202
Ensembl ID		ENSG00000196428	ENSG00000135945
Uniprot IDs		B4DN36 O75157	Q49AI5 Q9UBZ9
PDB IDs			2EBW 2LSI 2LSK 2LSY 2N1G 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5 5VZM 6ASR 6AXD 6WS0 6WS5
Enriched GO Terms of Interacting Partners?		Transporter Activator Activity Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transport Negative Regulation Of Pancreatic Juice Secretion Regulation Of Potassium Ion Import Regulation Of Sodium Ion Transmembrane Transport Proteasome Core Complex, Alpha-subunit Complex	Translesion Synthesis Postreplication Repair DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Error-prone Translesion Synthesis DNA-directed DNA Polymerase Activity DNA Polymerase Activity DNA Repair DNA Metabolic Process DNA Replication DNA Damage Response Zeta DNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Nucleotidyltransferase Activity Macromolecule Biosynthetic Process Cellular Response To Stress Nucleic Acid Metabolic Process Error-free Translesion Synthesis Nucleotide-excision Repair, DNA Gap Filling Damaged DNA Binding Response To Stress Nucleobase-containing Compound Metabolic Process Site Of Double-strand Break Nucleoplasm Nucleus Somatic Diversification Of Immunoglobulins Double-strand Break Repair DNA-templated DNA Replication DNA Damage Response, Signal Transduction Resulting In Transcription Macromolecule Metabolic Process Transferase Activity Atrial Cardiac Muscle Cell Development Cellular Response To UV DNA Synthesis Involved In UV-damage Excision Repair Delta DNA Polymerase Complex Cellular Response To Light Stimulus Cellular Response To UV-C DNA Binding Vascular Associated Smooth Muscle Cell Proliferation
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