TSC22D2 and SEC31A

Number of citations of the paper that reports this interaction (PubMedID 27337956)
0

Data Source:
BioGRID (two hybrid)

		TSC22D2	SEC31A
Description		TSC22 domain family member 2	SEC31 homolog A, COPII component
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Vesicle Coat COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Calcium-dependent Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Cell Cycle	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Protein Transport Vesicle-mediated Transport Response To Calcium Ion COPII-coated Vesicle Cargo Loading
Pathways			COPII-mediated vesicle transport MHC class II antigen presentation XBP1(S) activates chaperone genes Signaling by ALK fusions and activated point mutants Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 30297969 30054458) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult asthma ( 27611488) Femur bone mineral density x serum urate levels interaction ( 34046847) Neutrophil percentage of white cells ( 27863252)
Interacting Genes		43 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 USP7 WNK3 ZMYM2 ZNF143 ZNF251	15 interacting genes: APC ARIH1 FHL5 LCOR MYOM2 PDCD6 PEF1 PFDN1 PRNP REL SEC13 TNNT1 TSC1 TSC22D2 USP8
Entrez ID		9819	22872
HPRD ID		11101	15314
Ensembl ID		ENSG00000196428	ENSG00000138674
Uniprot IDs		B4DN36 O75157	A0A1S5UZ19 D6REX3 O94979
PDB IDs			3WXA 7SUL
Enriched GO Terms of Interacting Partners?		Transporter Activator Activity Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transport Negative Regulation Of Pancreatic Juice Secretion Regulation Of Potassium Ion Import Regulation Of Sodium Ion Transmembrane Transport Proteasome Core Complex, Alpha-subunit Complex	COPII Vesicle Coat ER To Golgi Transport Vesicle Membrane Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination Cul3-RING Ubiquitin Ligase Complex Neural Crest Formation Negative Regulation Of TOR Signaling Regulation Of Amyloid Fibril Formation Vesicle Organization COPII Vesicle Coating Regulation Of Supramolecular Fiber Organization Regulation Of TOR Signaling Neural Crest Cell Development Stem Cell Development Vesicle Coating Sarcomere Organization Type 8 Metabotropic Glutamate Receptor Binding Slow-twitch Skeletal Muscle Fiber Contraction Memory T Cell Differentiation Regulation Of Protein Metabolic Process Protein Folding Chaperone Mitotic Cytokinesis Negative Regulation Of Protein Metabolic Process Postsynaptic Density Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling PKR/eIFalpha Signaling
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