REV1 and REV3L

Number of citations of the paper that reports this interaction (PMID 15189446)
57

Data Source:
HPRD (two hybrid)

		REV1	REV3L
Gene Name		REV1, polymerase (DNA directed)	REV3-like, polymerase (DNA directed), zeta, catalytic subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Nucleolus Zeta DNA Polymerase Complex
	Molecular Function	Magnesium Ion Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Deoxycytidyl Transferase Activity	Nucleotide Binding DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Replication DNA Repair Response To UV Error-prone Translesion Synthesis	DNA-dependent DNA Replication DNA Repair Error-prone Translesion Synthesis
Pathways		DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template Translesion synthesis by HREV1	Translesion synthesis by Pol zeta DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: FHL2 MAD2L2 POLDIP2 POLH POLI POLK POLL REV3L	5 interactors: CHEK2 HDAC4 MAD2L1 MAD2L2 REV1
Entrez ID		51455	5980
HPRD ID		16202	04145
Ensembl ID		ENSG00000135945	ENSG00000009413
Uniprot IDs		Q9UBZ9	O60673
PDB IDs		2EBW 2LSI 2LSK 2LSY 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5
Enriched GO Terms of Interacting Partners?		DNA Biosynthetic Process DNA Repair DNA Replication Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Postreplication Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Nitrogen Compound Metabolic Process Nucleotide-excision Repair DNA-dependent DNA Replication Cellular Response To Stimulus Atrial Cardiac Muscle Cell Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Error-prone Translesion Synthesis Negative Regulation Of APC-Cdc20 Complex Activity Negative Regulation Of Transcription By Competitive Promoter Binding Response To Stimulus Translesion Synthesis Response To UV-C Pyrimidine Dimer Repair DNA Damage Response, Signal Transduction Resulting In Transcription Somatic Hypermutation Of Immunoglobulin Genes Heart Trabecula Formation DNA Synthesis Involved In DNA Repair Negative Regulation Of Transcription Regulatory Region DNA Binding Somatic Diversification Of Immune Receptors Via Somatic Mutation Nucleotide-excision Repair, DNA Gap Filling Ventricular Cardiac Muscle Cell Development Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription Regulatory Region DNA Binding Mitochondrion Morphogenesis Heart Trabecula Morphogenesis Ventricular Cardiac Muscle Cell Differentiation	Negative Regulation Of APC-Cdc20 Complex Activity Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Nuclear Division Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Division Negative Regulation Of Cell Cycle Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Signal Transduction In Response To DNA Damage DNA Repair Negative Regulation Of Protein Ubiquitination Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Cell Cycle Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Cell Cycle Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Tagcloud ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief sensing short specialized starvation sumo2 suppressor therapies toxic turn	adriamycin cgi cgis cox7a2l cpg damaging deal distinctly enrichment hct116 hnrpul1 island jag2 mildly pcna peroxidase phenomena repressed scenarios scfd2 stabilize stabilized stresses syvn1 tor1aip1 unchanged varies verified xpmc2h
Tagcloud (Difference) ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief sensing short specialized starvation sumo2 suppressor therapies toxic turn	adriamycin cgi cgis cox7a2l cpg damaging deal distinctly enrichment hct116 hnrpul1 island jag2 mildly pcna peroxidase phenomena repressed scenarios scfd2 stabilize stabilized stresses syvn1 tor1aip1 unchanged varies verified xpmc2h
Tagcloud (Intersection) ?