TSC22D2 and SPEF2

Number of citations of the paper that reports this interaction (PubMedID 27337956)
0

Data Source:
BioGRID (two hybrid)

		TSC22D2	SPEF2
Description		TSC22 domain family member 2	sperm flagellar 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Manchette Extracellular Region Cytoplasm Golgi Apparatus Cytosol Cilium Nuclear Body Motile Cilium Sperm Flagellum Cell Projection Sperm Midpiece
	Molecular Function	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Cell Cycle	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Spermatogenesis Sperm Axoneme Assembly Cell Differentiation Skeletal System Morphogenesis Brain Morphogenesis Respiratory System Development
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 30297969 30054458) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Advanced age-related macular degeneration ( 26691988) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma or allergic disease (pleiotropy) ( 29785011) Hemoglobin levels ( 33491795) Homeostasis model assessment of insulin resistance ( 33381925) Periventricular white matter hyperintensities ( 32517579) Primary biliary cirrhosis ( 22961000) Pulse pressure x educational attainment (some college) interaction (2df) ( 32372009) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		43 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 USP7 WNK3 ZMYM2 ZNF143 ZNF251	2 interacting genes: MTDH TSC22D2
Entrez ID		9819	79925
HPRD ID		11101	11181
Ensembl ID		ENSG00000196428	ENSG00000152582
Uniprot IDs		B4DN36 O75157	A0A140VKD0 Q9C093
PDB IDs
Enriched GO Terms of Interacting Partners?		Transporter Activator Activity Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transport Negative Regulation Of Pancreatic Juice Secretion Regulation Of Potassium Ion Import Regulation Of Sodium Ion Transmembrane Transport Proteasome Core Complex, Alpha-subunit Complex
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