TSC22D2 and MED13

Number of citations of the paper that reports this interaction (PubMedID 27337956)
0

Data Source:
BioGRID (two hybrid)

		TSC22D2	MED13
Description		TSC22 domain family member 2	mediator complex subunit 13
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Membrane Mediator Complex CKM Complex
	Molecular Function	Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cholesterol Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II Triglyceride Homeostasis
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32154731 32203549) Type 2 diabetes ( 30297969 30054458) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Coffee consumption ( 31046077) Initial pursuit acceleration ( 29064472) Objective response to lithium treatment ( 26503763) PR segment duration ( 24850809)
Interacting Genes		43 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 USP7 WNK3 ZMYM2 ZNF143 ZNF251	9 interacting genes: ENO1 ESR1 LCOR MED12 MED13L MED23 MED9 SREBF1 TSC22D2
Entrez ID		9819	9969
HPRD ID		11101	07229
Ensembl ID		ENSG00000196428	ENSG00000108510
Uniprot IDs		B4DN36 O75157	Q9UHV7
PDB IDs			8T9D 8TQ2 8TQC 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Transporter Activator Activity Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transport Negative Regulation Of Pancreatic Juice Secretion Regulation Of Potassium Ion Import Regulation Of Sodium Ion Transmembrane Transport Proteasome Core Complex, Alpha-subunit Complex	Mediator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Binding RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Axis Elongation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Core Mediator Complex Positive Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Cellular Response To Estradiol Stimulus Positive Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Binding Transcription Coregulator Binding Positive Regulation Of Metabolic Process Nuclear Receptor Activity Transcription Coactivator Activity Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of MiRNA Transcription Nucleoplasm Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Axis Elongation Involved In Somitogenesis Beta-catenin Binding Regulation Of DNA-templated Transcription Elongation Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Response To Estradiol Prostate Epithelial Cord Elongation
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