TSC22D2 and EPCAM

Number of citations: 0 (PubMedID 27337956)
Data Source: BioGRID (two hybrid)

		TSC22D2	EPCAM
Name		TSC22 domain family member 2	epithelial cell adhesion molecule
Structure		No pdb structure
GO Annotations	Cellular Component	None	Plasma Membrane Bicellular Tight Junction Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding	Protein Binding Protein-containing Complex Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Cell Cycle	Ureteric Bud Development Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Stem Cell Proliferation
Pathways		None	Cell surface interactions at the vascular wall Attachment of bacteria to epithelial cells Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs		None	Oportuzumab monatox ING-1 Catumaxomab Technetium Tc-99m nofetumomab merpentan Hypromellose
Diseases		None	Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		A body shape index ( 34021172 ) Adiponectin levels ( 22479202 ) Apolipoprotein A1 levels ( 32203549 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Cortical surface area (MOSTest) ( 32665545 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Glaucoma ( 31959993 ) Glaucoma (primary open-angle) ( 33627673 29891935 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Intraocular pressure ( 29235454 ) Macular thickness ( 30535121 ) Mean platelet volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 ) Moyamoya disease ( 29273593 ) PR interval ( 32439900 ) Pulse pressure ( 27841878 ) Refractive error ( 32231278 ) Subcortical volume (MOSTest) ( 32665545 ) Systolic blood pressure ( 27841878 ) T wave morphology restitution during recovery from exercise ( 31607149 ) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149 ) Triglyceride levels ( 32154731 32203549 ) Type 2 diabetes ( 30297969 30054458 ) Waist circumference ( 26785701 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	epithelial cell adhesion molecule levels ( 25147954 ) Severe insulin-deficient type 2 diabetes ( 34737425 )
Interacting Genes		43 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 USP7 WNK3 ZMYM2 ZNF143 ZNF251	2 interacting genes: CLDN7 TSC22D2
Entrez ID		9819	4072
HPRD ID		11101	01709
Ensembl ID		ENSG00000196428	ENSG00000119888
Uniprot IDs		B4DN36 O75157	P16422
PDB IDs		Not available	4MZV 6I07
GO Terms Enriched among Interactors		Transporter Activator Activity Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transport Negative Regulation Of Pancreatic Juice Secretion Regulation Of Potassium Ion Import Regulation Of Sodium Ion Transmembrane Transport Proteasome Core Complex, Alpha-subunit Complex	None