REV1 and MAD2L2

Number of citations of the paper that reports this interaction (PMID 11485998)
59

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		REV1	MAD2L2
Gene Name		REV1, polymerase (DNA directed)	MAD2 mitotic arrest deficient-like 2 (yeast)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Zeta DNA Polymerase Complex
	Molecular Function	Magnesium Ion Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Deoxycytidyl Transferase Activity	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding
	Biological Process	DNA Replication DNA Repair Response To UV Error-prone Translesion Synthesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Growth DNA Repair Double-strand Break Repair Transcription, DNA-templated Actin Filament Organization Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of APC-Cdc20 Complex Activity Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template Translesion synthesis by HREV1	Translesion synthesis by Pol zeta DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		8 interactors: FHL2 MAD2L2 POLDIP2 POLH POLI POLK POLL REV3L	22 interactors: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 ELK1 IKZF1 KCTD9 MAD2L1 POLDIP2 PRCC PRRC2A RBBP6 REL REV1 REV3L SFI1 TCF4 TRIM27 TRIP13 YY1AP1
Entrez ID		51455	10459
HPRD ID		16202	07246
Ensembl ID		ENSG00000135945	ENSG00000116670
Uniprot IDs		Q9UBZ9	Q9UI95
PDB IDs		2EBW 2LSI 2LSK 2LSY 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5
Enriched GO Terms of Interacting Partners?		DNA Biosynthetic Process DNA Repair DNA Replication Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Postreplication Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Nitrogen Compound Metabolic Process Nucleotide-excision Repair DNA-dependent DNA Replication Cellular Response To Stimulus Atrial Cardiac Muscle Cell Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Error-prone Translesion Synthesis Negative Regulation Of APC-Cdc20 Complex Activity Negative Regulation Of Transcription By Competitive Promoter Binding Response To Stimulus Translesion Synthesis Response To UV-C Pyrimidine Dimer Repair DNA Damage Response, Signal Transduction Resulting In Transcription Somatic Hypermutation Of Immunoglobulin Genes Heart Trabecula Formation DNA Synthesis Involved In DNA Repair Negative Regulation Of Transcription Regulatory Region DNA Binding Somatic Diversification Of Immune Receptors Via Somatic Mutation Nucleotide-excision Repair, DNA Gap Filling Ventricular Cardiac Muscle Cell Development Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription Regulatory Region DNA Binding Mitochondrion Morphogenesis Heart Trabecula Morphogenesis Ventricular Cardiac Muscle Cell Differentiation	Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Process Extracellular Matrix Disassembly PMA-inducible Membrane Protein Ectodomain Proteolysis Mitotic Cell Cycle Error-prone Translesion Synthesis Response To Stress Regulation Of Meiosis Regulation Of Meiotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Collagen Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Translesion Synthesis Cell Cycle Checkpoint Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cell Adhesion Mediated By Integrin Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Division Multicellular Organismal Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Synapse Maturation Negative Regulation Of Transferase Activity Membrane Protein Ectodomain Proteolysis Regulation Of Synapse Maturation Postreplication Repair Cellular Response To Stress Proteolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Membrane Protein Proteolysis Tissue Development Negative Regulation Of Catalytic Activity Spindle Assembly Checkpoint Positive Regulation Of Protein Metabolic Process Innate Immune Response
Tagcloud ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief sensing short specialized starvation sumo2 suppressor therapies toxic turn	arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves
Tagcloud (Difference) ?		augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief sensing short specialized starvation sumo2 suppressor therapies toxic turn	arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves
Tagcloud (Intersection) ?