SEC31A and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SEC31A	PFDN1
Description		SEC31 homolog A, COPII component	prefoldin subunit 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Vesicle Coat COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function	Structural Molecule Activity Protein Binding Calcium-dependent Protein Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Protein Transport Vesicle-mediated Transport Response To Calcium Ion COPII-coated Vesicle Cargo Loading	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		COPII-mediated vesicle transport MHC class II antigen presentation XBP1(S) activates chaperone genes Signaling by ALK fusions and activated point mutants Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Adult asthma ( 27611488) Femur bone mineral density x serum urate levels interaction ( 34046847) Neutrophil percentage of white cells ( 27863252)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		15 interacting genes: APC ARIH1 FHL5 LCOR MYOM2 PDCD6 PEF1 PFDN1 PRNP REL SEC13 TNNT1 TSC1 TSC22D2 USP8	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		22872	5201
HPRD ID		15314	05357
Ensembl ID		ENSG00000138674	ENSG00000113068
Uniprot IDs		A0A1S5UZ19 D6REX3 O94979	O60925
PDB IDs		3WXA 7SUL	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		COPII Vesicle Coat ER To Golgi Transport Vesicle Membrane Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination Cul3-RING Ubiquitin Ligase Complex Neural Crest Formation Negative Regulation Of TOR Signaling Regulation Of Amyloid Fibril Formation Vesicle Organization COPII Vesicle Coating Regulation Of Supramolecular Fiber Organization Regulation Of TOR Signaling Neural Crest Cell Development Stem Cell Development Vesicle Coating Sarcomere Organization Type 8 Metabotropic Glutamate Receptor Binding Slow-twitch Skeletal Muscle Fiber Contraction Memory T Cell Differentiation Regulation Of Protein Metabolic Process Protein Folding Chaperone Mitotic Cytokinesis Negative Regulation Of Protein Metabolic Process Postsynaptic Density Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling PKR/eIFalpha Signaling	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization
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