SEC31A and PEF1

Number of citations of the paper that reports this interaction (PubMedID 35120648)
60

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		SEC31A	PEF1
Description		SEC31 homolog A, COPII component	penta-EF-hand domain containing 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Vesicle Coat COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Cytoplasm Endoplasmic Reticulum ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Calcium-dependent Protein Binding	RNA Binding Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Protein Transport Vesicle-mediated Transport Response To Calcium Ion COPII-coated Vesicle Cargo Loading	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development COPII Vesicle Coating Response To Calcium Ion Positive Regulation Of Protein Monoubiquitination
Pathways		COPII-mediated vesicle transport MHC class II antigen presentation XBP1(S) activates chaperone genes Signaling by ALK fusions and activated point mutants Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Adult asthma ( 27611488) Femur bone mineral density x serum urate levels interaction ( 34046847) Neutrophil percentage of white cells ( 27863252)	Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566) Hypoalbuminemia ( 34050200) Intelligence (MTAG) ( 29326435) Severe aortic features in Marfan syndrome ( 30087447)
Interacting Genes		15 interacting genes: APC ARIH1 FHL5 LCOR MYOM2 PDCD6 PEF1 PFDN1 PRNP REL SEC13 TNNT1 TSC1 TSC22D2 USP8	40 interacting genes: AKAP8L ALG2 ANKRD10 BAG4 BPIFA1 CALCOCO2 CEP55 CFAP68 CTAG1A CTAG1B DAZAP2 DMRTB1 EIF4G1 EWSR1 FAM168A FOXR2 HEMK1 HGS HYDIN INCA1 KRTAP12-1 KRTAP15-1 KRTAP19-1 MED25 METTL15 NR0B2 PDCD6 SEC24A SEC31A SMUG1 SOHLH1 SPAG8 SPG21 STH TFG UBC USP9X VPS37C WWOX ZIC1
Entrez ID		22872	553115
HPRD ID		15314	10143
Ensembl ID		ENSG00000138674	ENSG00000162517
Uniprot IDs		A0A1S5UZ19 D6REX3 O94979	A0A384MQX5 Q9UBV8
PDB IDs		3WXA 7SUL	8RBH
Enriched GO Terms of Interacting Partners?		COPII Vesicle Coat ER To Golgi Transport Vesicle Membrane Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination Cul3-RING Ubiquitin Ligase Complex Neural Crest Formation Negative Regulation Of TOR Signaling Regulation Of Amyloid Fibril Formation Vesicle Organization COPII Vesicle Coating Regulation Of Supramolecular Fiber Organization Regulation Of TOR Signaling Neural Crest Cell Development Stem Cell Development Vesicle Coating Sarcomere Organization Type 8 Metabotropic Glutamate Receptor Binding Slow-twitch Skeletal Muscle Fiber Contraction Memory T Cell Differentiation Regulation Of Protein Metabolic Process Protein Folding Chaperone Mitotic Cytokinesis Negative Regulation Of Protein Metabolic Process Postsynaptic Density Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling PKR/eIFalpha Signaling	Endoplasmic Reticulum Exit Site COPII Vesicle Coat Protein Binding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
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