SEC31A and MYOM2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		SEC31A	MYOM2
Description		SEC31 homolog A, COPII component	myomesin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Vesicle Coat COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Cytoplasm Mitochondrion M Band Myosin Filament
	Molecular Function	Structural Molecule Activity Protein Binding Calcium-dependent Protein Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Muscle Kinase Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Protein Transport Vesicle-mediated Transport Response To Calcium Ion COPII-coated Vesicle Cargo Loading	Extraocular Skeletal Muscle Development Muscle Contraction Sarcomere Organization
Pathways		COPII-mediated vesicle transport MHC class II antigen presentation XBP1(S) activates chaperone genes Signaling by ALK fusions and activated point mutants Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Adult asthma ( 27611488) Femur bone mineral density x serum urate levels interaction ( 34046847) Neutrophil percentage of white cells ( 27863252)	Ankylosing spondylitis ( 30946743) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density x serum urate levels interaction ( 34046847) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Opioid use cessation ( 31936517) Toenail selenium levels ( 25343990)
Interacting Genes		15 interacting genes: APC ARIH1 FHL5 LCOR MYOM2 PDCD6 PEF1 PFDN1 PRNP REL SEC13 TNNT1 TSC1 TSC22D2 USP8	14 interacting genes: ANKRD1 CKM DYSF HSPB2 JMJD1C MYBPC2 MYH7 MYH9 NEB RPS6 SEC31A TAF1 TNNT1 TTN
Entrez ID		22872	9172
HPRD ID		15314	04619
Ensembl ID		ENSG00000138674	ENSG00000036448
Uniprot IDs		A0A1S5UZ19 D6REX3 O94979	P54296
PDB IDs		3WXA 7SUL
Enriched GO Terms of Interacting Partners?		COPII Vesicle Coat ER To Golgi Transport Vesicle Membrane Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination Cul3-RING Ubiquitin Ligase Complex Neural Crest Formation Negative Regulation Of TOR Signaling Regulation Of Amyloid Fibril Formation Vesicle Organization COPII Vesicle Coating Regulation Of Supramolecular Fiber Organization Regulation Of TOR Signaling Neural Crest Cell Development Stem Cell Development Vesicle Coating Sarcomere Organization Type 8 Metabotropic Glutamate Receptor Binding Slow-twitch Skeletal Muscle Fiber Contraction Memory T Cell Differentiation Regulation Of Protein Metabolic Process Protein Folding Chaperone Mitotic Cytokinesis Negative Regulation Of Protein Metabolic Process Postsynaptic Density Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling PKR/eIFalpha Signaling	Sarcomere Organization Actomyosin Structure Organization Actin Filament-based Process Myosin Filament Somatic Muscle Development Actin-mediated Cell Contraction Skeletal Muscle Contraction Actin Cytoskeleton Organization Structural Constituent Of Muscle Myofibril Transition Between Fast And Slow Fiber Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Actin Filament Binding Muscle Tissue Morphogenesis Supramolecular Fiber Regulation Of Skeletal Muscle Adaptation Striated Muscle Contraction Muscle Filament Sliding Actin-myosin Filament Sliding Actin Binding M Band Cardiac Muscle Hypertrophy Z Disc Myosin II Complex Response To Muscle Stretch I Band Muscle Hypertrophy Microfilament Motor Activity Calmodulin Binding Muscle Contraction Cardiac Muscle Contraction Cytoskeleton Organization Myosin Complex Cytoskeletal Motor Activity Cortical Granule Exocytosis Positive Regulation Of Androgen Receptor Signaling Pathway Slow-twitch Skeletal Muscle Fiber Contraction Monocyte Activation Involved In Immune Response Sarcomere Muscle System Process Regulation Of The Force Of Skeletal Muscle Contraction Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Uropod Organization Actin Cytoskeleton Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Negative Regulation Of Protein Autoubiquitination P53 Binding Titin-telethonin Complex
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