GCSH and MIS18A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GCSH	MIS18A
Description		glycine cleavage system protein H	MIS18 kinetochore protein A
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol CENP-A Recruiting Complex
	Molecular Function	Aminomethyltransferase Activity Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System	Chromosome Segregation Heterochromatin Formation CENP-A Containing Chromatin Assembly Cell Division Protein Localization To Chromosome, Centromeric Region Pericentric Heterochromatin Organization
Pathways		Glycine degradation Protein lipoylation	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs		6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Glycine levels ( 30837465 31070104) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: CIDEB ING5 MAGEA11 MAGEA6 MED11 MIS18A NMI RHBDD2 SFI1 ZBTB16	30 interacting genes: ABI3 AIMP2 AMOT ATG14 BRD8 C1orf216 CNGA3 DMAP1 FNDC11 GCSH GLYCTK IFT20 MAFIP MBIP MIS18BP1 NDEL1 NTAQ1 NUP58 OIP5 PPP1R13B RTP5 STX11 STX17 TEDC2 THAP1 TSGA10IP TXLNA VMA22 ZNF471 ZNF655
Entrez ID		2653	54069
HPRD ID		01998	10749
Ensembl ID		ENSG00000140905	ENSG00000159055
Uniprot IDs		P23434	Q9NYP9
PDB IDs			7SFY 7SFZ 8S30
Enriched GO Terms of Interacting Partners?			Pericentric Heterochromatin Organization CENP-A Recruiting Complex Autophagosome Membrane Docking Swr1 Complex CENP-A Containing Chromatin Assembly Organelle Localization By Membrane Tethering
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