MATR3 and TRAF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		MATR3	TRAF1
Description		matrin 3	TNF receptor associated factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Membrane Nuclear Matrix	Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Structural Molecule Activity Protein Binding Zinc Ion Binding MiRNA Binding Identical Protein Binding Metal Ion Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding
	Biological Process	Blastocyst Formation Activation Of Innate Immune Response Immune System Process Heart Valve Development Ventricular Septum Development Post-transcriptional Regulation Of Gene Expression Innate Immune Response	Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Protein-containing Complex Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Body mass index ( 26426971) Malaria ( 31844061) Metabolite levels ( 23823483)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 24782177 23143596 30891314 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) White blood cell count ( 32888494)
Interacting Genes		102 interacting genes: AIMP2 AKTIP CALM1 CDC42 EGFR ERG GFI1B HNRNPK HTR2B KRT27 KRT34 LINC01232 LMNA MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NRON PCBP1 PCBP3 PLEKHG4 PTBP2 PTEN RASD1 RNF10 SNAP23 SRPK2 TNFRSF21 TRAF1 TRAF6 TSGA10 TTF2 UBE2I USP7	244 interacting genes: A1CF ABHD17A ACTN3 AIRIM AKAP17A AQP1 ARID5A ARNT2 ARSJ BARD1 BCAS2 BCL6 BEX2 BEX3 BIRC2 BIRC3 C1orf216 CARHSP1 CASP10 CASP3 CASP6 CASP8 CATSPERT CCDC116 CCDC120 CCDC146 CCDC185 CCDC187 CCDC198 CCHCR1 CD40 CDCA3 CDK18 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRACR2A CRY2 CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 DUSP13B DUSP21 DUSP4 EBF2 EDAR EHHADH ENKD1 EWSR1 FAM161A FAM161B FAM86C1P FBF1 FBXL18 FOSL2 GADD45GIP1 GATA1 GATA2 GATAD2B GCA GCM2 GEM GFI1B GIT2 GLIS3 GLRX3 GMCL2 GNG5 GOLGA2 GORASP2 GRAP2 HAUS1 HELT HEY2 HGS HIVEP3 HMG20B HNRNPM HOXA1 HOXB5 HOXC8 HOXD12 IKBKB JOSD1 KANK2 KIAA1217 KIF1A KLHL38 KPNA2 KRT3 KRT75 LCOR LIN37 LMNTD2 LNX1 LNX2 LRRN1 LTBR MACIR MAP3K14 MAP6 MAPRE2 MATR3 METTL17 MORN3 MOS MSGN1 MYEF2 MYOZ1 NEBL NOL4L-DT NTAQ1 NUFIP2 NUP58 OLIG3 PATZ1 PBX3 PDE4D PHF21A PIN1 PITX1 PITX2 PKN1 PLAC8 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PRKAB2 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RCOR3 RIIAD1 RIPK1 RIPK2 RIPOR3 RIPPLY1 RNF31 RTP5 SAMD11 SAXO4 SCNM1 SDCBP2 SH3GLB2 SHARPIN SHC3 SHFL SIK3 SLC25A48 SLC25A6 SNRNP25 SNW1 SOHLH1 SPATA46 SPG21 SPMIP2 SPOP SRC SSC5D STK3 SUMO2 SYCE1 TANK TBC1D16 TBC1D8 TBX18 TCEA2 TCF7L2 TCL1A TEAD4 TFAP2D TFAP4 TFPT THAP7 TICAM1 TIFA TLE5 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSHZ2 TSSC4 USP2 USP7 UTP14C VEZF1 WAC ZBTB1 ZBTB16 ZC2HC1C ZFYVE21 ZFYVE26 ZIC1 ZNF124 ZNF20 ZNF23 ZNF250 ZNF417 ZNF440 ZNF490 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF627 ZNF648 ZNF662 ZNF669 ZNF688 ZNF697 ZNF844
Entrez ID		9782	7185
HPRD ID		05270	03418
Ensembl ID		ENSG00000015479	ENSG00000056558
Uniprot IDs		A0A0R4J2E8 A8MXP9 B3KM87 B4DF66 P43243 Q9H4N1	Q13077
PDB IDs			3M0D 5E1T 5H10
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Locomotion Negative Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Stability Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Signal Transduction Regulation Of MRNA Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Tumor Necrosis Factor-mediated Signaling Pathway Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Activity Zinc Ion Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Non-canonical NF-kappaB Signal Transduction Nucleus DNA Binding Ripoptosome CD40 Receptor Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Necroptotic Process Death-inducing Signaling Complex Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Programmed Necrotic Cell Death Programmed Cell Death Cell Death CD40 Signaling Pathway Positive Regulation Of Programmed Cell Death Cytokine-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Necroptotic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Identical Protein Binding Apoptotic Signaling Pathway Sequence-specific Double-stranded DNA Binding Protein Linear Polyubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Death Receptor Binding
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