MATR3 and NRON

Number of citations of the paper that reports this interaction (PubMedID 37382239)
47

Data Source:
BioGRID (unspecified method)

		MATR3	NRON
Description		matrin 3	non-coding repressor of NFAT
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Membrane Nuclear Matrix
	Molecular Function	Nucleic Acid Binding RNA Binding Structural Molecule Activity Protein Binding Zinc Ion Binding MiRNA Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Blastocyst Formation Activation Of Innate Immune Response Immune System Process Heart Valve Development Ventricular Septum Development Post-transcriptional Regulation Of Gene Expression Innate Immune Response
Pathways
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Body mass index ( 26426971) Malaria ( 31844061) Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Eyebrow thickness ( 26926045) Malaria ( 31844061)
Interacting Genes		102 interacting genes: AIMP2 AKTIP CALM1 CDC42 EGFR ERG GFI1B HNRNPK HTR2B KRT27 KRT34 LINC01232 LMNA MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NRON PCBP1 PCBP3 PLEKHG4 PTBP2 PTEN RASD1 RNF10 SNAP23 SRPK2 TNFRSF21 TRAF1 TRAF6 TSGA10 TTF2 UBE2I USP7	8 interacting genes: HNRNPU KHSRP MATR3 MDM2 MDM4 NFATC2 NUMB TP53
Entrez ID		9782	641373
HPRD ID		05270
Ensembl ID		ENSG00000015479
Uniprot IDs		A0A0R4J2E8 A8MXP9 B3KM87 B4DF66 P43243 Q9H4N1
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Locomotion Negative Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Stability Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Signal Transduction Regulation Of MRNA Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Heart Valve Development Ventricular Septum Development Cellular Response To Actinomycin D Response To Actinomycin D Cardiac Septum Development DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To UV-C Transcription Repressor Complex Atrial Septum Development Cellular Response To Antibiotic Signal Transduction By P53 Class Mediator Response To UV-C Negative Regulation Of Transcription By RNA Polymerase II Nuclear Matrix Cellular Response To Hypoxia Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Response To Decreased Oxygen Levels Endocardial Cushion Morphogenesis Signal Transduction In Response To DNA Damage Atrioventricular Valve Morphogenesis Cellular Response To Oxygen Levels Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Disordered Domain Specific Binding Cellular Response To Gamma Radiation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process 14-3-3 Protein Binding Regulation Of ATP-dependent Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Negative Regulation Of Telomere Maintenance Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Ribonucleoprotein Complex Binding Negative Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Transcription By RNA Polymerase II Neuroblast Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Biological Quality Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Response To Xenobiotic Stimulus DNA Damage Response Response To Hypoxia Response To Gamma Radiation
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